Nature Communications (Jul 2017)
A peptide-based viral inactivator inhibits Zika virus infection in pregnant mice and fetuses
- Yufeng Yu,
- Yong-Qiang Deng,
- Peng Zou,
- Qian Wang,
- Yanyan Dai,
- Fei Yu,
- Lanying Du,
- Na-Na Zhang,
- Min Tian,
- Jia-Nan Hao,
- Yu Meng,
- Yuan Li,
- Xiaohui Zhou,
- Jasper Fuk-Woo Chan,
- Kwok-Yung Yuen,
- Cheng-Feng Qin,
- Shibo Jiang,
- Lu Lu
Affiliations
- Yufeng Yu
- Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University
- Yong-Qiang Deng
- State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology
- Peng Zou
- Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University
- Qian Wang
- Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University
- Yanyan Dai
- Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University
- Fei Yu
- Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University
- Lanying Du
- Lindsley F. Kimball Research Institute, New York Blood Center
- Na-Na Zhang
- State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology
- Min Tian
- Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University
- Jia-Nan Hao
- State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology
- Yu Meng
- Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University
- Yuan Li
- Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University
- Xiaohui Zhou
- Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University
- Jasper Fuk-Woo Chan
- Department of Microbiology, State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong
- Kwok-Yung Yuen
- Department of Microbiology, State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong
- Cheng-Feng Qin
- State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology
- Shibo Jiang
- Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University
- Lu Lu
- Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University
- DOI
- https://doi.org/10.1038/ncomms15672
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 12
Abstract
Zika virus (ZIKV) has spread rapidly in recent years and there is a need for antiviral treatments. Here, the authors develop an antiviral peptide, based on the stem region of ZIKV envelope protein, and show that it is safe in pregnant mice and inhibits ZIKV infection in pregnant mice and fetuses.
