Nature Communications (Jul 2019)
Time series modeling of cell cycle exit identifies Brd4 dependent regulation of cerebellar neurogenesis
- Clara Penas,
- Marie E. Maloof,
- Vasileios Stathias,
- Jun Long,
- Sze Kiat Tan,
- Jose Mier,
- Yin Fang,
- Camilo Valdes,
- Jezabel Rodriguez-Blanco,
- Cheng-Ming Chiang,
- David J. Robbins,
- Daniel J. Liebl,
- Jae K. Lee,
- Mary E. Hatten,
- Jennifer Clarke,
- Nagi G. Ayad
Affiliations
- Clara Penas
- Department of Psychiatry and Behavioral Sciences, Center for Therapeutic Innovation, Sylvester Comprehensive Cancer Center, Miami Project to Cure Paralysis, University of Miami Miller School of Medicine
- Marie E. Maloof
- Department of Psychiatry and Behavioral Sciences, Center for Therapeutic Innovation, Sylvester Comprehensive Cancer Center, Miami Project to Cure Paralysis, University of Miami Miller School of Medicine
- Vasileios Stathias
- Department of Psychiatry and Behavioral Sciences, Center for Therapeutic Innovation, Sylvester Comprehensive Cancer Center, Miami Project to Cure Paralysis, University of Miami Miller School of Medicine
- Jun Long
- Department of Surgery, University of Miami Miller School of Medicine
- Sze Kiat Tan
- Department of Psychiatry and Behavioral Sciences, Center for Therapeutic Innovation, Sylvester Comprehensive Cancer Center, Miami Project to Cure Paralysis, University of Miami Miller School of Medicine
- Jose Mier
- Department of Neurosurgery, Miami Project to Cure Paralysis, University of Miami Miller School of Medicine
- Yin Fang
- Laboratory of Development Neurobiology, The Rockefeller University
- Camilo Valdes
- Computing and Information Sciences, Florida International University
- Jezabel Rodriguez-Blanco
- Department of Surgery, University of Miami Miller School of Medicine
- Cheng-Ming Chiang
- Simmons Comprehensive Cancer Center, Department of Biochemistry and Department of Pharmacology, University of Texas Southwestern Medical Center
- David J. Robbins
- Department of Surgery, University of Miami Miller School of Medicine
- Daniel J. Liebl
- Department of Neurosurgery, Miami Project to Cure Paralysis, University of Miami Miller School of Medicine
- Jae K. Lee
- Department of Neurosurgery, Miami Project to Cure Paralysis, University of Miami Miller School of Medicine
- Mary E. Hatten
- Laboratory of Development Neurobiology, The Rockefeller University
- Jennifer Clarke
- Department of Statistics, University of Nebraska
- Nagi G. Ayad
- Department of Psychiatry and Behavioral Sciences, Center for Therapeutic Innovation, Sylvester Comprehensive Cancer Center, Miami Project to Cure Paralysis, University of Miami Miller School of Medicine
- DOI
- https://doi.org/10.1038/s41467-019-10799-5
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 11
Abstract
The mechanisms controlling irreversible cell cycle exit in cerebellar granule progenitors (GCPs) have not been fully elucidated. Here, the authors performed RNA-sequencing of GCPs exiting the cell cycle to identify downregulation of Brd4 activity as an early event during cell cycle exit which subsequently regulates Shh activity and is needed for proper cerebellar development
