BME Frontiers (Jan 2021)
Bioresorbable Multilayer Photonic Cavities as Temporary Implants for Tether-Free Measurements of Regional Tissue Temperatures
- Wubin Bai,
- Masahiro Irie,
- Zhonghe Liu,
- Haiwen Luan,
- Daniel Franklin,
- Khizar Nandoliya,
- Hexia Guo,
- Hao Zang,
- Yang Weng,
- Di Lu,
- Di Wu,
- Yixin Wu,
- Joseph Song,
- Mengdi Han,
- Enming Song,
- Yiyuan Yang,
- Xuexian Chen,
- Hangbo Zhao,
- Wei Lu,
- Giuditta Monti,
- Iwona Stepien,
- Irawati Kandela,
- Chad R. Haney,
- Changsheng Wu,
- Sang Min Won,
- Hanjun Ryu,
- Alina Rwei,
- Haixu Shen,
- Jihye Kim,
- Hong-Joon Yoon,
- Wei Ouyang,
- Yihan Liu,
- Emily Suen,
- Huang-yu Chen,
- Jerry Okina,
- Jushen Liang,
- Yonggang Huang,
- Guillermo A. Ameer,
- Weidong Zhou,
- John A. Rogers
Affiliations
- Wubin Bai
- Department of Materials Science and Engineering, Northwestern University, Evanston, Illinois 60208, USA; Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, Illinois 60208, USA
- Masahiro Irie
- Department of Materials Science and Engineering, Northwestern University, Evanston, Illinois 60208, USA; Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, Illinois 60208, USA
- Zhonghe Liu
- Department of Electrical Engineering, University of Texas at Arlington, Arlington, TX 76019, USA
- Haiwen Luan
- Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, Illinois 60208, USA; Department of Mechanical Engineering, Northwestern University, Evanston, Illinois 60208, USA
- Daniel Franklin
- Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, Illinois 60208, USA
- Khizar Nandoliya
- Department of Chemistry, Northwestern University, Evanston, Illinois 60208, USA
- Hexia Guo
- Department of Materials Science and Engineering, Northwestern University, Evanston, Illinois 60208, USA; Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, Illinois 60208, USA
- Hao Zang
- Department of Materials Science and Engineering, Northwestern University, Evanston, Illinois 60208, USA
- Yang Weng
- Department of Materials Science and Engineering, Northwestern University, Evanston, Illinois 60208, USA
- Di Lu
- Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, Illinois 60208, USA
- Di Wu
- Department of Biomedical Engineering, Northwestern University, Evanston, Illinois 60208, USA
- Yixin Wu
- Department of Materials Science and Engineering, Northwestern University, Evanston, Illinois 60208, USA; Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, Illinois 60208, USA
- Joseph Song
- Department of Biomedical Engineering, Northwestern University, Evanston, Illinois 60208, USA
- Mengdi Han
- Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, Illinois 60208, USA
- Enming Song
- Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, Illinois 60208, USA; Department of Materials Science and Engineering, University of Illinois Urbana-Champaign, Urbana, Illinois 61801, USA
- Yiyuan Yang
- Department of Materials Science and Engineering, Northwestern University, Evanston, Illinois 60208, USA; Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, Illinois 60208, USA
- Xuexian Chen
- Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, Illinois 60208, USA; Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China
- Hangbo Zhao
- Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, Illinois 60208, USA; Department of Aerospace and Mechanical Engineering, University of Southern California, Los Angeles, CA 90089, USA
- Wei Lu
- Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, Illinois 60208, USA
- Giuditta Monti
- Department of Biomedical Engineering, Northwestern University, Evanston, Illinois 60208, USA
- Iwona Stepien
- The Center for Developmental Therapeutics, Northwestern University, Evanston, Illinois 60208, USA
- Irawati Kandela
- Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, Illinois 60208, USA
- Chad R. Haney
- Department of Biomedical Engineering, Northwestern University, Evanston, Illinois 60208, USA; Center for Advanced Molecular Imaging, Northwestern University, Evanston, Illinois 60208, USA
- Changsheng Wu
- Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, Illinois 60208, USA
- Sang Min Won
- Department of Electrical and Computer Engineering, Sungkyunkwan University, Suwon, Republic of Korea
- Hanjun Ryu
- Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, Illinois 60208, USA
- Alina Rwei
- Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, Illinois 60208, USA
- Haixu Shen
- Department of Materials Science and Engineering, Northwestern University, Evanston, Illinois 60208, USA; Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, Illinois 60208, USA
- Jihye Kim
- Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, Illinois 60208, USA; School of Advanced Materials Science and Engineering, Sungkyunkwan University (SKKU), Suwon 16419, Republic of Korea
- Hong-Joon Yoon
- Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, Illinois 60208, USA; School of Advanced Materials Science and Engineering, Sungkyunkwan University (SKKU), Suwon 16419, Republic of Korea
- Wei Ouyang
- Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, Illinois 60208, USA
- Yihan Liu
- Department of Materials Science and Engineering, Northwestern University, Evanston, Illinois 60208, USA
- Emily Suen
- Department of Neurobiology, Northwestern University, Evanston, Illinois 60208, USA
- Huang-yu Chen
- Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, Illinois 60208, USA
- Jerry Okina
- Department of Chemical Engineering, Northwestern University, Evanston, Illinois 60208, USA
- Jushen Liang
- Department of Chemical Engineering, Northwestern University, Evanston, Illinois 60208, USA
- Yonggang Huang
- Department of Materials Science and Engineering, Northwestern University, Evanston, Illinois 60208, USA; Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, Illinois 60208, USA; Department of Mechanical Engineering, Northwestern University, Evanston, Illinois 60208, USA; Department of Civil and Environmental Engineering, Northwestern University, Evanston, Illinois 60208, USA
- Guillermo A. Ameer
- Department of Biomedical Engineering, Northwestern University, Evanston, Illinois 60208, USA; Department of Electrical Engineering and Computer Science, Northwestern University, Evanston, Illinois 60208, USA; Northwestern Medicine, Feinberg School of Medicine, Northwestern University, Evanston, Illinois 60208, USA; Center for Advanced Regenerative Engineering, Northwestern University, Evanston, Illinois 60208, USA
- Weidong Zhou
- Department of Electrical Engineering, University of Texas at Arlington, Arlington, TX 76019, USA
- John A. Rogers
- Department of Materials Science and Engineering, Northwestern University, Evanston, Illinois 60208, USA; Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, Illinois 60208, USA; Department of Mechanical Engineering, Northwestern University, Evanston, Illinois 60208, USA; Department of Chemistry, Northwestern University, Evanston, Illinois 60208, USA; Department of Biomedical Engineering, Northwestern University, Evanston, Illinois 60208, USA; Department of Electrical Engineering and Computer Science, Northwestern University, Evanston, Illinois 60208, USA; Northwestern Medicine, Feinberg School of Medicine, Northwestern University, Evanston, Illinois 60208, USA; Center for Advanced Regenerative Engineering, Northwestern University, Evanston, Illinois 60208, USA
- DOI
- https://doi.org/10.34133/2021/8653218
- Journal volume & issue
-
Vol. 2021
Abstract
Objective and Impact Statement. Real-time monitoring of the temperatures of regional tissue microenvironments can serve as the diagnostic basis for treating various health conditions and diseases. Introduction. Traditional thermal sensors allow measurements at surfaces or at near-surface regions of the skin or of certain body cavities. Evaluations at depth require implanted devices connected to external readout electronics via physical interfaces that lead to risks for infection and movement constraints for the patient. Also, surgical extraction procedures after a period of need can introduce additional risks and costs. Methods. Here, we report a wireless, bioresorbable class of temperature sensor that exploits multilayer photonic cavities, for continuous optical measurements of regional, deep-tissue microenvironments over a timeframe of interest followed by complete clearance via natural body processes. Results. The designs decouple the influence of detection angle from temperature on the reflection spectra, to enable high accuracy in sensing, as supported by in vitro experiments and optical simulations. Studies with devices implanted into subcutaneous tissues of both awake, freely moving and asleep animal models illustrate the applicability of this technology for in vivo measurements. Conclusion. The results demonstrate the use of bioresorbable materials in advanced photonic structures with unique capabilities in tracking of thermal signatures of tissue microenvironments, with potential relevance to human healthcare.
