Nature Communications (Sep 2020)
Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults
- Edith Hofer,
- Gennady V. Roshchupkin,
- Hieab H. H. Adams,
- Maria J. Knol,
- Honghuang Lin,
- Shuo Li,
- Habil Zare,
- Shahzad Ahmad,
- Nicola J. Armstrong,
- Claudia L. Satizabal,
- Manon Bernard,
- Joshua C. Bis,
- Nathan A. Gillespie,
- Michelle Luciano,
- Aniket Mishra,
- Markus Scholz,
- Alexander Teumer,
- Rui Xia,
- Xueqiu Jian,
- Thomas H. Mosley,
- Yasaman Saba,
- Lukas Pirpamer,
- Stephan Seiler,
- James T. Becker,
- Owen Carmichael,
- Jerome I. Rotter,
- Bruce M. Psaty,
- Oscar L. Lopez,
- Najaf Amin,
- Sven J. van der Lee,
- Qiong Yang,
- Jayandra J. Himali,
- Pauline Maillard,
- Alexa S. Beiser,
- Charles DeCarli,
- Sherif Karama,
- Lindsay Lewis,
- Mat Harris,
- Mark E. Bastin,
- Ian J. Deary,
- A. Veronica Witte,
- Frauke Beyer,
- Markus Loeffler,
- Karen A. Mather,
- Peter R. Schofield,
- Anbupalam Thalamuthu,
- John B. Kwok,
- Margaret J. Wright,
- David Ames,
- Julian Trollor,
- Jiyang Jiang,
- Henry Brodaty,
- Wei Wen,
- Meike W. Vernooij,
- Albert Hofman,
- André G. Uitterlinden,
- Wiro J. Niessen,
- Katharina Wittfeld,
- Robin Bülow,
- Uwe Völker,
- Zdenka Pausova,
- G. Bruce Pike,
- Sophie Maingault,
- Fabrice Crivello,
- Christophe Tzourio,
- Philippe Amouyel,
- Bernard Mazoyer,
- Michael C. Neale,
- Carol E. Franz,
- Michael J. Lyons,
- Matthew S. Panizzon,
- Ole A. Andreassen,
- Anders M. Dale,
- Mark Logue,
- Katrina L. Grasby,
- Neda Jahanshad,
- Jodie N. Painter,
- Lucía Colodro-Conde,
- Janita Bralten,
- Derrek P. Hibar,
- Penelope A. Lind,
- Fabrizio Pizzagalli,
- Jason L. Stein,
- Paul M. Thompson,
- Sarah E. Medland,
- ENIGMA consortium,
- Perminder S. Sachdev,
- William S. Kremen,
- Joanna M. Wardlaw,
- Arno Villringer,
- Cornelia M. van Duijn,
- Hans J. Grabe,
- William T. Longstreth,
- Myriam Fornage,
- Tomas Paus,
- Stephanie Debette,
- M. Arfan Ikram,
- Helena Schmidt,
- Reinhold Schmidt,
- Sudha Seshadri
Affiliations
- Edith Hofer
- Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz
- Gennady V. Roshchupkin
- Department of Radiology and Nuclear Medicine, Erasmus MC
- Hieab H. H. Adams
- Department of Radiology and Nuclear Medicine, Erasmus MC
- Maria J. Knol
- Department of Epidemiology, Erasmus MC
- Honghuang Lin
- Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine
- Shuo Li
- Department of Biostatistics, Boston University School of Public Health
- Habil Zare
- Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases, UT Health San Antonio
- Shahzad Ahmad
- Department of Epidemiology, Erasmus MC
- Nicola J. Armstrong
- Mathematics and Statistics, Murdoch University
- Claudia L. Satizabal
- Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases, UT Health San Antonio
- Manon Bernard
- Hospital for Sick Children
- Joshua C. Bis
- Cardiovascular Health Research Unit, Department of Medicine, Epidemiology and Health Services, University of Washington
- Nathan A. Gillespie
- Virginia Institute for Psychiatric and Behavior Genetics, Virginia Commonwealth University
- Michelle Luciano
- Centre for Cognitive Epidemiology and Cognitive Ageing, University of Edinburgh
- Aniket Mishra
- University of Bordeaux, Bordeaux Population Health Research Center, INSERM UMR 1219
- Markus Scholz
- Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig
- Alexander Teumer
- Institute for Community Medicine, University Medicine Greifswald
- Rui Xia
- Institute of Molecular Medicine and Human Genetics Center, University of Texas Health Science Center at Houston
- Xueqiu Jian
- Institute of Molecular Medicine and Human Genetics Center, University of Texas Health Science Center at Houston
- Thomas H. Mosley
- Department of Medicine, University of Mississippi Medical Center
- Yasaman Saba
- Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz
- Lukas Pirpamer
- Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz
- Stephan Seiler
- Imaging of Dementia and Aging (IDeA) Laboratory, Department of Neurology, University of California-Davis
- James T. Becker
- Departments of Psychiatry, Neurology, and Psychology, University of Pittsburgh
- Owen Carmichael
- Pennington Biomedical Research Center
- Jerome I. Rotter
- Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Pediatrics at Harbor-UCLA Medical Center
- Bruce M. Psaty
- Cardiovascular Health Research Unit, Department of Medicine, Epidemiology and Health Services, University of Washington
- Oscar L. Lopez
- Departments of Psychiatry, Neurology, and Psychology, University of Pittsburgh
- Najaf Amin
- Department of Epidemiology, Erasmus MC
- Sven J. van der Lee
- Department of Epidemiology, Erasmus MC
- Qiong Yang
- Department of Biostatistics, Boston University School of Public Health
- Jayandra J. Himali
- Department of Biostatistics, Boston University School of Public Health
- Pauline Maillard
- Imaging of Dementia and Aging (IDeA) Laboratory, Department of Neurology, University of California-Davis
- Alexa S. Beiser
- Department of Biostatistics, Boston University School of Public Health
- Charles DeCarli
- Imaging of Dementia and Aging (IDeA) Laboratory, Department of Neurology, University of California-Davis
- Sherif Karama
- McGill University, Montreal Neurological Institute
- Lindsay Lewis
- McGill University, Montreal Neurological Institute
- Mat Harris
- Centre for Cognitive Epidemiology and Cognitive Ageing, University of Edinburgh
- Mark E. Bastin
- Centre for Cognitive Epidemiology and Cognitive Ageing, University of Edinburgh
- Ian J. Deary
- Centre for Cognitive Epidemiology and Cognitive Ageing, University of Edinburgh
- A. Veronica Witte
- Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences
- Frauke Beyer
- Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences
- Markus Loeffler
- Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig
- Karen A. Mather
- Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales
- Peter R. Schofield
- Neuroscience Research Australia
- Anbupalam Thalamuthu
- Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales
- John B. Kwok
- School of Medical Sciences, University of New South Wales
- Margaret J. Wright
- Queensland Brain Institute, The University of Queensland
- David Ames
- National Ageing Research Institute, Royal Melbourne Hospital
- Julian Trollor
- Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales
- Jiyang Jiang
- Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales
- Henry Brodaty
- Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales
- Wei Wen
- Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales
- Meike W. Vernooij
- Department of Radiology and Nuclear Medicine, Erasmus MC
- Albert Hofman
- Department of Epidemiology, Erasmus MC
- André G. Uitterlinden
- Department of Epidemiology, Erasmus MC
- Wiro J. Niessen
- Department of Radiology and Nuclear Medicine, Erasmus MC
- Katharina Wittfeld
- German Center for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald
- Robin Bülow
- Institute for Diagnostic Radiology and Neuroradiology, University Medicine Greifswald
- Uwe Völker
- Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald
- Zdenka Pausova
- Hospital for Sick Children
- G. Bruce Pike
- Departments of Radiology and Clinial Neurosciences, University of Calgary
- Sophie Maingault
- Institut des Maladies Neurodégénratives UMR5293, CEA, CNRS, University of Bordeaux
- Fabrice Crivello
- Institut des Maladies Neurodégénratives UMR5293, CEA, CNRS, University of Bordeaux
- Christophe Tzourio
- University of Bordeaux, Bordeaux Population Health Research Center, INSERM UMR 1219
- Philippe Amouyel
- Centre Hospitalier Universitaire de Bordeaux, France; Inserm U1167
- Bernard Mazoyer
- Institut des Maladies Neurodégénratives UMR5293, CEA, CNRS, University of Bordeaux
- Michael C. Neale
- Virginia Institute for Psychiatric and Behavior Genetics, Virginia Commonwealth University
- Carol E. Franz
- Department of Psychiatry, University of California San Diego
- Michael J. Lyons
- Department of Psychological and Brain Sciences, Boston University
- Matthew S. Panizzon
- Department of Psychiatry, University of California San Diego
- Ole A. Andreassen
- NORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital
- Anders M. Dale
- Departments of Radiology and Neurosciences, University of California, San Diego
- Mark Logue
- Department of Biostatistics, Boston University School of Public Health
- Katrina L. Grasby
- Psychiatric Genetics, QIMR Berghofer Medical Research Institute
- Neda Jahanshad
- Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California
- Jodie N. Painter
- Psychiatric Genetics, QIMR Berghofer Medical Research Institute
- Lucía Colodro-Conde
- Psychiatric Genetics, QIMR Berghofer Medical Research Institute
- Janita Bralten
- Department of Human Genetics, Radboud university medical center
- Derrek P. Hibar
- Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California
- Penelope A. Lind
- Psychiatric Genetics, QIMR Berghofer Medical Research Institute
- Fabrizio Pizzagalli
- Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California
- Jason L. Stein
- Department of Genetics & UNC Neuroscience Center, University of North Carolina at Chapel Hill
- Paul M. Thompson
- Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California
- Sarah E. Medland
- Psychiatric Genetics, QIMR Berghofer Medical Research Institute
- ENIGMA consortium
- Perminder S. Sachdev
- Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales
- William S. Kremen
- Department of Psychiatry, University of California San Diego
- Joanna M. Wardlaw
- Centre for Cognitive Epidemiology and Cognitive Ageing, University of Edinburgh
- Arno Villringer
- Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences
- Cornelia M. van Duijn
- Department of Epidemiology, Erasmus MC
- Hans J. Grabe
- German Center for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald
- William T. Longstreth
- Departments of Neurology and Epidemiology, University of Washington
- Myriam Fornage
- Institute of Molecular Medicine and Human Genetics Center, University of Texas Health Science Center at Houston
- Tomas Paus
- Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital
- Stephanie Debette
- Department of Neurology, Boston University School of Medicine
- M. Arfan Ikram
- Department of Radiology and Nuclear Medicine, Erasmus MC
- Helena Schmidt
- Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz
- Reinhold Schmidt
- Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz
- Sudha Seshadri
- Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases, UT Health San Antonio
- DOI
- https://doi.org/10.1038/s41467-020-18367-y
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 16
Abstract
Cortex morphology varies with age, cognitive function, and in neurological and psychiatric diseases. Here the authors report 160 genome-wide significant associations with thickness, surface area and volume of the total cortex and 34 cortical regions from a GWAS meta-analysis in 22,824 adults.
