N-{N-[N-(1,1-Dimethylethoxycarbonyl)-l-leucyl]-N-methyl-l-leucyl}-N-methyl-l-leucine benzyl ester

Abstract

The tripeptide title compound, C32H53N3O6, synthesized in 80% yield by coupling of N-methyl-l-leucine benzyl ester with tert-butoxycarbonyl-l-leucyl-N-methyl-l-leucine at 273 K, conjugates through two amide linkages and includes two protecting groups: a tert-butyloxycarbonyl group at the C-tip and a benzyl group at the N-tip. A classical intermolecular N—H...O hydrogen bond and a weak non-conventional intermolecular C—H...O contact connect the molecules, forming layers parallel to (001).