مجلة كلية الطب (Oct 2022)
D-dimer level and Wells score in women undergone Lymphadenectomy in Gynecological Cancer to Assess Risk of Deep Venous Thrombosis
Abstract
Background: Cancers of the female reproductive system - are an important cause of cancer morbidity and mortality worldwide. A deep-vein thrombosis is a blood clot that forms within the deep veins, usually of the leg. The D-Dimer is a by-product of the blood clotting and break-down process that can be measured via analysis of a blood sample. Aim of the study: To predict the risk of deep venous thrombosis by used serum D-dimer and wells score after pelvic lymphadenectomy in gynecological cancer. Patients and method: a prospective observational cross-sectional study was carried out in the Department of Obstetrics and Gynecology/ Baghdad Teaching Hospital, from 1 January 2021 to 30 Dec. 2021. A total number of 45 (22 endometrial cancer, 12 ovarian, 11 cervical cancer). Results: the mean level of pre-operative D-dimer in endometrial cancer was (423.2± 123.9) while in post-operative was (987±125.1), the mean level of pre-operative D-dimer in ovarian cancer was (602±320.7) while in post-operative was (901.5± 412), mean level of pre-operative D-dimer in cervical cancer was (339±157) while in postoperative was (1214±327), and the mean level of pre-operative D-dimer in all gynecological cancer was (541±167) while in post-operative was (1016±302). The mean of wells score of those who are likely to developed DVT(n=7)in pre-op. was(2.3±0.02)while for those who unlikely to develop DVT(38)was(2.03±0.4)with statistically significant difference(p=0.04)while highly significant difference found in pre and post operatively between the group of DVT(p˂0.001). Conclusion: Highly significant increase of post-operative D-dimer in all gynecological cancer patients.
