Characterization of Organic Molecules Grafted to Silica or Bismuth Nanoparticles by NMR
Céline Henoumont,
Gauthier Hallot,
Estelle Lipani,
Catherine Gomez,
Robert N. Muller,
Luce Vander Elst,
Marc Port,
Sophie Laurent
Affiliations
Céline Henoumont
General, Organic and Biomedical Chemistry Unit, NMR and Molecular Imaging Laboratory, University of Mons, 19 Avenue Maistriau, 7000 Mons, Belgium
Gauthier Hallot
Laboratoire de Génomique, Bioinformatique et Chimie Moléculaire (EA 7528), Equipe Chimie Moléculaire, Conservatoire National des Arts et Métiers (Cnam), HESAM Université, 2 Rue Conté, 75003 Paris, France
Estelle Lipani
General, Organic and Biomedical Chemistry Unit, NMR and Molecular Imaging Laboratory, University of Mons, 19 Avenue Maistriau, 7000 Mons, Belgium
Catherine Gomez
Laboratoire de Génomique, Bioinformatique et Chimie Moléculaire (EA 7528), Equipe Chimie Moléculaire, Conservatoire National des Arts et Métiers (Cnam), HESAM Université, 2 Rue Conté, 75003 Paris, France
Robert N. Muller
General, Organic and Biomedical Chemistry Unit, NMR and Molecular Imaging Laboratory, University of Mons, 19 Avenue Maistriau, 7000 Mons, Belgium
Luce Vander Elst
General, Organic and Biomedical Chemistry Unit, NMR and Molecular Imaging Laboratory, University of Mons, 19 Avenue Maistriau, 7000 Mons, Belgium
Marc Port
Laboratoire de Génomique, Bioinformatique et Chimie Moléculaire (EA 7528), Equipe Chimie Moléculaire, Conservatoire National des Arts et Métiers (Cnam), HESAM Université, 2 Rue Conté, 75003 Paris, France
Sophie Laurent
General, Organic and Biomedical Chemistry Unit, NMR and Molecular Imaging Laboratory, University of Mons, 19 Avenue Maistriau, 7000 Mons, Belgium
NMR is a powerful characterization tool and we propose to study the surface of silica or bismuth nanoparticles dedicated to medical applications in order to evidence the covalent grafting of organic molecules on their surface. For that aim, DOSY experiments are particularly useful and allow for the discrimination of molecules interacting strongly with the nanoparticle surface from molecules simply weakly adsorbed at the surface. We were able to characterize thoroughly the surface of different silica and bismuth nanoparticles.
