Nature Communications (Jun 2022)
Molecularly cleavable bioinks facilitate high-performance digital light processing-based bioprinting of functional volumetric soft tissues
- Mian Wang,
- Wanlu Li,
- Jin Hao,
- Arthur Gonzales,
- Zhibo Zhao,
- Regina Sanchez Flores,
- Xiao Kuang,
- Xuan Mu,
- Terry Ching,
- Guosheng Tang,
- Zeyu Luo,
- Carlos Ezio Garciamendez-Mijares,
- Jugal Kishore Sahoo,
- Michael F. Wells,
- Gengle Niu,
- Prajwal Agrawal,
- Alfredo Quiñones-Hinojosa,
- Kevin Eggan,
- Yu Shrike Zhang
Affiliations
- Mian Wang
- Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School
- Wanlu Li
- Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School
- Jin Hao
- Department of Stem Cell and Regenerative Biology, Harvard University
- Arthur Gonzales
- University of the Philippines Diliman
- Zhibo Zhao
- Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School
- Regina Sanchez Flores
- Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School
- Xiao Kuang
- Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School
- Xuan Mu
- Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School
- Terry Ching
- Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School
- Guosheng Tang
- Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School
- Zeyu Luo
- Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School
- Carlos Ezio Garciamendez-Mijares
- Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School
- Jugal Kishore Sahoo
- Department of Biomedical Engineering, Tufts University
- Michael F. Wells
- Department of Stem Cell and Regenerative Biology, Harvard University
- Gengle Niu
- Department of Stem Cell and Regenerative Biology, Harvard University
- Prajwal Agrawal
- Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School
- Alfredo Quiñones-Hinojosa
- Departments of Neurosurgery, Oncology, Neuroscience, Mayo Clinic
- Kevin Eggan
- Department of Stem Cell and Regenerative Biology, Harvard University
- Yu Shrike Zhang
- Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School
- DOI
- https://doi.org/10.1038/s41467-022-31002-2
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 18
Abstract
Soft tissue fabrication using digital light processing remains challenging. Here the authors present a molecular cleavage approach to achieve high-performance bioprinting of constructs with tissue-matching mechanical properties and structural complexity.
