Targeting PPARα in low ambient temperature exposure-induced cardiac dysfunction and remodeling

Abstract

Abstract The present study demonstrates that the down-regulation of peroxisome proliferator-activated receptor-α (PPARα) results in chronic low ambient temperature (LT) exposure-induced cardiac dysfunction and remodeling, emphasizing the therapeutic potential of PPARα activation strategies (e.g. fenofibrate treatment) in LT-associated cardiac injury.

Keywords

• Low ambient temperature
• Cardiac dysfunction
• Remodeling
• Peroxisome proliferator-activated receptor-α
• Fatty acid metabolism