Endothelial pannexin-1 channels modulate macrophage and smooth muscle cell activation in abdominal aortic aneurysm formation

Amanda C. Filiberto; Michael D. Spinosa; Craig T. Elder; Gang Su; Victoria Leroy; Zachary Ladd; Guanyi Lu; J. Hunter Mehaffey; Morgan D. Salmon; Robert B. Hawkins; Kodi S. Ravichandran; Brant E. Isakson; Gilbert R. Upchurch; Ashish K. Sharma

doi:10.1038/s41467-022-29233-4

Nature Communications (Mar 2022)

Endothelial pannexin-1 channels modulate macrophage and smooth muscle cell activation in abdominal aortic aneurysm formation

Amanda C. Filiberto,
Michael D. Spinosa,
Craig T. Elder,
Gang Su,
Victoria Leroy,
Zachary Ladd,
Guanyi Lu,
J. Hunter Mehaffey,
Morgan D. Salmon,
Robert B. Hawkins,
Kodi S. Ravichandran,
Brant E. Isakson,
Gilbert R. Upchurch,
Ashish K. Sharma

Affiliations

Amanda C. Filiberto: Department of Surgery, University of Florida
Michael D. Spinosa: Department of Surgery, University of Virginia
Craig T. Elder: Department of Surgery, University of Florida
Gang Su: Department of Surgery, University of Florida
Victoria Leroy: Department of Surgery, University of Florida
Zachary Ladd: Department of Surgery, University of Florida
Guanyi Lu: Department of Surgery, University of Florida
J. Hunter Mehaffey: Department of Surgery, University of Virginia
Morgan D. Salmon: Department of Surgery, University of Virginia
Robert B. Hawkins: Department of Surgery, University of Virginia
Kodi S. Ravichandran: Department of Microbiology, Immunology and Cancer Biology, University of Virginia
Brant E. Isakson: Department of Molecular Physiology and Biological Physics, University of Virginia
Gilbert R. Upchurch: Department of Surgery, University of Florida
Ashish K. Sharma: Department of Surgery, University of Florida

DOI: https://doi.org/10.1038/s41467-022-29233-4
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 11

Abstract

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Pannexin-1 ion channels on endothelial cells regulate vascular inflammation and remodeling to mediate aortic aneurysm formation. Pharmacological blockade of Pannexin-1 channels may offer translational therapeutic mitigation of aneurysmal pathology.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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