An original biomarker for the risk of developing cardiovascular diseases and their complications: Telomere length

Natalya A. Doroschuk; Anton Yu Postnov; Alexander D. Doroschuk; Anastasia I. Ryzhkova; Vasily V. Sinyov; Marina D. Sazonova; Victoria A. Khotina; Alexander N. Orekhov; Igor A. Sobenin; Margarita A. Sazonova

Toxicology Reports (Jan 2021)

An original biomarker for the risk of developing cardiovascular diseases and their complications: Telomere length

Natalya A. Doroschuk,
Anton Yu Postnov,
Alexander D. Doroschuk,
Anastasia I. Ryzhkova,
Vasily V. Sinyov,
Marina D. Sazonova,
Victoria A. Khotina,
Alexander N. Orekhov,
Igor A. Sobenin,
Margarita A. Sazonova

Affiliations

Natalya A. Doroschuk: Institute of General Pathology and Pathophysiology, Laboratory of Angiopathology, 8, Baltiyskaya Str., Moscow, 125315, Russian Federation; National Medical Research Center of Cardiology Ministry of Health Products RF, Laboratory of Medical Genetics, 15a, 3rd Cherepkovskaya Str., Moscow, 121552, Russian Federation
Anton Yu Postnov: National Medical Research Center of Cardiology Ministry of Health Products RF, Laboratory of Medical Genetics, 15a, 3rd Cherepkovskaya Str., Moscow, 121552, Russian Federation; Research Institute of Human Morphology, Laboratory of Cellular and Molecular Pathology of Cardiovascular System, 3, Tsyurupa Street, 117418, Moscow, Russian Federation
Alexander D. Doroschuk: Institute of General Pathology and Pathophysiology, Laboratory of Angiopathology, 8, Baltiyskaya Str., Moscow, 125315, Russian Federation; National Medical Research Center of Cardiology Ministry of Health Products RF, Laboratory of Medical Genetics, 15a, 3rd Cherepkovskaya Str., Moscow, 121552, Russian Federation
Anastasia I. Ryzhkova: Institute of General Pathology and Pathophysiology, Laboratory of Angiopathology, 8, Baltiyskaya Str., Moscow, 125315, Russian Federation
Vasily V. Sinyov: Institute of General Pathology and Pathophysiology, Laboratory of Angiopathology, 8, Baltiyskaya Str., Moscow, 125315, Russian Federation; National Medical Research Center of Cardiology Ministry of Health Products RF, Laboratory of Medical Genetics, 15a, 3rd Cherepkovskaya Str., Moscow, 121552, Russian Federation
Marina D. Sazonova: Institute of General Pathology and Pathophysiology, Laboratory of Angiopathology, 8, Baltiyskaya Str., Moscow, 125315, Russian Federation
Victoria A. Khotina: Institute of General Pathology and Pathophysiology, Laboratory of Angiopathology, 8, Baltiyskaya Str., Moscow, 125315, Russian Federation; Research Institute of Human Morphology, Laboratory of Cellular and Molecular Pathology of Cardiovascular System, 3, Tsyurupa Street, 117418, Moscow, Russian Federation
Alexander N. Orekhov: Institute of General Pathology and Pathophysiology, Laboratory of Angiopathology, 8, Baltiyskaya Str., Moscow, 125315, Russian Federation; Institute for Atherosclerosis Research, Skolkovo Innovative Centre, 100, Novaya Str., Skolkovo village, Odintsovsky District, Moscow Region, 143085, Russian Federation; Research Institute of Human Morphology, Laboratory of Cellular and Molecular Pathology of Cardiovascular System, 3, Tsyurupa Street, 117418, Moscow, Russian Federation
Igor A. Sobenin: Institute of General Pathology and Pathophysiology, Laboratory of Angiopathology, 8, Baltiyskaya Str., Moscow, 125315, Russian Federation; National Medical Research Center of Cardiology Ministry of Health Products RF, Laboratory of Medical Genetics, 15a, 3rd Cherepkovskaya Str., Moscow, 121552, Russian Federation
Margarita A. Sazonova: Institute of General Pathology and Pathophysiology, Laboratory of Angiopathology, 8, Baltiyskaya Str., Moscow, 125315, Russian Federation; National Medical Research Center of Cardiology Ministry of Health Products RF, Laboratory of Medical Genetics, 15a, 3rd Cherepkovskaya Str., Moscow, 121552, Russian Federation; Corresponding author at: Laboratory of angiopathology, Institute of General Pathology and Pathophysiology, 8, Baltiyskaya Str., Moscow, Russian Federation.

Journal volume & issue: Vol. 8
pp. 499 – 504

Abstract

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Aim: The aim of this work was to study the effect of telomere length in the chromosomes of nuclear blood cells in individuals with coronary heart disease (CHD) on the development of cardiovascular complications (CVC). Materials and methods: DNA was isolated from nuclear blood cells of 498 study participants. The telomere length was determined by real-time polymerase chain reaction. The investigation of each sample was repeated three times. Five years after the end of this study, a telephone survey of 119 patients with CHD was conducted in order to obtain data on the presence of CVC. Results: According to the results obtained, a decrease in telomere length in patients with coronary heart disease increases the risk of subsequent development of cardiovascular complications. Conclusion: Patients with coronary heart disease with shorter telomeres compared with conventionally healthy study participants had an increased risk of cardiovascular complications within 5 years after telomere analysis.

Published in Toxicology Reports

ISSN: 2214-7500 (Online)
Publisher: Elsevier
Country of publisher: Ireland
LCC subjects: Medicine: Public aspects of medicine: Toxicology. Poisons
Website: http://www.journals.elsevier.com/toxicology-reports/

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