Cycloferon as an Agents of Antirelpsing Therapy in Patients with Chronic Hyperplastic Sinusitis

Abstract

The data on the efficacy of cycloferon as an agents of antirelapsing therapy in management of 123 patients with chronic hyperplastic sinusitis are presented. The drug induction of endogenous interferons was validated by the properties of the local mucosal immunity, virus invasion and virus persistence in the nasal and accessory nasal sinuses mucosa, as well as by different levels of the interferon production deficiency. The clinical efficacy was stated in 53% of the cases. The relapses were recorded in 13.1% of the patients treated with cycloferon vs. 33.3% of the patients under the local corticosteroid therapy.

Keywords

• chronic hyperplastic sinusitis
• cycloferon
• antirelapsing therapy
• interferon response