Intractable chronic granulomatous perioral dermatitis in patients receiving growth hormone therapy: A new association between CGPD and GH

Abstract

Childhood granulomatous periorificial dermatitis (CGPD) is a self-limiting skin condition characterized by papular eruptions around the mouth, nose and eyes of preadolescent children. We report two cases of intractable CGPD in which patients receiving growth hormone (GH) therapy showed persistent symptoms despite multiple treatment modalities. This association may suggest the role of GH in the pathogenesis of CGPD.

Keywords

• chronic granulomatous perioral dermatitis
• cytokine-like action
• growth hormone therapy