Sexual health and testosterone concentration in male lymphoma survivors: A systematic review
Signe Micas Pedersen,
Ditte Stampe Hersby,
Mary Jarden,
Torsten Holm Nielsen,
Anne Ortved Gang,
Christian Bjørn Poulsen,
Peter de Nully Brown,
Niels Jørgensen,
Claus Larsen Feltoft,
Lars Møller Pedersen
Affiliations
Signe Micas Pedersen
Department of Hematology, Copenhagen University Hospital - Rigshospitalet, Blegdamsvej 9, 2100, KBH Ø, Denmark; Department of Oncology, Copenhagen University Hospital – Herlev and Gentofte, Borgmester Ib Juuls Vej 1, 2730, Herlev, Denmark; Corresponding author. Mailing address: Enebærhaven 24, 3500, Værløse, Denmark.
Ditte Stampe Hersby
Department of Hematology, Copenhagen University Hospital - Rigshospitalet, Blegdamsvej 9, 2100, KBH Ø, Denmark
Mary Jarden
Department of Hematology, Copenhagen University Hospital - Rigshospitalet, Blegdamsvej 9, 2100, KBH Ø, Denmark; Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, 2200 KBH N, Denmark
Torsten Holm Nielsen
Department of Hematology, Copenhagen University Hospital - Rigshospitalet, Blegdamsvej 9, 2100, KBH Ø, Denmark; Danish Medicines Agency, Axel Heides Gade 1, 2300, KBH S, Denmark
Anne Ortved Gang
Department of Hematology, Copenhagen University Hospital - Rigshospitalet, Blegdamsvej 9, 2100, KBH Ø, Denmark; Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, 2200 KBH N, Denmark
Christian Bjørn Poulsen
Department of Hematology, Zealand University Hospital, Vestermarksvej 15, 4000, Roskilde, Denmark
Peter de Nully Brown
Department of Hematology, Copenhagen University Hospital - Rigshospitalet, Blegdamsvej 9, 2100, KBH Ø, Denmark
Niels Jørgensen
Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Blegdamsvej 9, 2100, KBH Ø, Denmark
Claus Larsen Feltoft
Department of Endocrinology, Copenhagen University Hospital – Herlev and Gentofte, Borgmester Ib Juuls Vej 1, 2730, Herlev, Denmark
Lars Møller Pedersen
Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, 2200 KBH N, Denmark; Department of Hematology, Zealand University Hospital, Vestermarksvej 15, 4000, Roskilde, Denmark
Advancements in lymphoma treatment have increased the number of long-term survivors who may experience late effects such as impaired sexual function and testosterone deficiency. The aim of this review was to determine the prevalence of testosterone deficiency and sexual dysfunction among male lymphoma survivors; and associations between the two. A systematic search identified 20 articles for inclusion. The prevalence of low total testosterone was 0%–50 %, with mean values within reference levels, and for luteinizing hormone above reference levels in 0%–80 %. Four studies included SHBG and free testosterone, with mixed results. Compromised sexual health was found in 23%–61 %. Overall, total testosterone and sexual health were associated. The risk of bias (ROBINS-E and RoB 2) was high/very high, leading to low/very low overall confidence in the bulk of evidence (GRADE). Longitudinal studies evaluating biologically active testosterone and sexual health are needed, to develop evidence based standard procedures for follow-up of sexual health.
