Nature Communications (May 2021)

A dual-target molecular mechanism of pyrethrum repellency against mosquitoes

  • Feng Liu,
  • Qiang Wang,
  • Peng Xu,
  • Felipe Andreazza,
  • Wilson R. Valbon,
  • Elizabeth Bandason,
  • Mengli Chen,
  • Ru Yan,
  • Bo Feng,
  • Leticia B. Smith,
  • Jeffrey G. Scott,
  • Genki Takamatsu,
  • Makoto Ihara,
  • Kazuhiko Matsuda,
  • James Klimavicz,
  • Joel Coats,
  • Eugenio E. Oliveira,
  • Yuzhe Du,
  • Ke Dong

DOI
https://doi.org/10.1038/s41467-021-22847-0
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 9

Abstract

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Although pyrethrum is used to repel insects for centuries, the underlying mechanism has been enigmatic. Liu et al. found that specific components of pyrethrum mediate repellency by targeting olfactory receptors and/or voltage-gated sodium channels in Aedes aegypti mosquitoes.