Ligand recognition and biased agonism of the D1 dopamine receptor

Xiao Teng; Sijia Chen; Yingying Nie; Peng Xiao; Xiao Yu; Zhenhua Shao; Sanduo Zheng

doi:10.1038/s41467-022-30929-w

Nature Communications (Jun 2022)

Ligand recognition and biased agonism of the D1 dopamine receptor

Xiao Teng,
Sijia Chen,
Yingying Nie,
Peng Xiao,
Xiao Yu,
Zhenhua Shao,
Sanduo Zheng

Affiliations

Xiao Teng: Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University
Sijia Chen: National Institute of Biological Sciences
Yingying Nie: National Institute of Biological Sciences
Peng Xiao: Key Laboratory Experimental Teratology of the Ministry of Education and Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University
Xiao Yu: Key Laboratory Experimental Teratology of the Ministry of Education and Department of Physiology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University
Zhenhua Shao: Division of Nephrology and Kidney Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University
Sanduo Zheng: Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University

DOI: https://doi.org/10.1038/s41467-022-30929-w
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 11

Abstract

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D1 dopamine receptor is an important drug target for treatment of hypertension and Parkinson’s disease. Here, authors report three cryo-EM structures of the D1R-Gs complex bound to three distinct D1R-selective drugs.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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