PLoS ONE (Jan 2019)

Emphysema phenotypes and lung cancer risk.

  • Jessica González,
  • Claudia I Henschke,
  • David F Yankelevitz,
  • Luis M Seijo,
  • Anthony P Reeves,
  • Rowena Yip,
  • Yiting Xie,
  • Michael Chung,
  • Pablo Sánchez-Salcedo,
  • Ana B Alcaide,
  • Aranzazu Campo,
  • Juan Bertó,
  • María Del Mar Ocón,
  • Jesus Pueyo,
  • Gorka Bastarrika,
  • Juan P de-Torres,
  • Javier J Zulueta

DOI
https://doi.org/10.1371/journal.pone.0219187
Journal volume & issue
Vol. 14, no. 7
p. e0219187

Abstract

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BackgroundTo assess the relationship between lung cancer and emphysema subtypes.ObjectiveAirflow obstruction and emphysema predispose to lung cancer. Little is known, however, about the lung cancer risk associated with different emphysema phenotypes. We assessed the risk of lung cancer based on the presence, type and severity of emphysema, using visual assessment.MethodsSeventy-two consecutive lung cancer cases were selected from a prospective cohort of 3,477 participants enrolled in the Clínica Universidad de Navarra's lung cancer screening program. Each case was matched to three control subjects using age, sex, smoking history and body mass index as key variables. Visual assessment of emphysema and spirometry were performed. Logistic regression and interaction model analysis were used in order to investigate associations between lung cancer and emphysema subtypes.ResultsAirflow obstruction and visual emphysema were significantly associated with lung cancer (OR = 2.8, 95%CI: 1.6 to 5.2; OR = 5.9, 95%CI: 2.9 to 12.2; respectively). Emphysema severity and centrilobular subtype were associated with greater risk when adjusted for confounders (OR = 12.6, 95%CI: 1.6 to 99.9; OR = 34.3, 95%CI: 25.5 to 99.3, respectively). The risk of lung cancer decreases with the added presence of paraseptal emphysema (OR = 4.0, 95%CI: 3.6 to 34.9), losing this increased risk of lung cancer when it occurs alone (OR = 0.7, 95%CI: 0.5 to 2.6).ConclusionsVisual scoring of emphysema predicts lung cancer risk. The centrilobular phenotype is associated with the greatest risk.