A human pluripotent stem cell line KUMi004-A generated from a patient with chronic lymphocytic leukemia

Ji-Hea Kim; Ka-Won Kang; Byung-Hyun Lee; Young Park; Hwa Jung Sung; Byung-Soo Kim

Stem Cell Research (Apr 2022)

A human pluripotent stem cell line KUMi004-A generated from a patient with chronic lymphocytic leukemia

Ji-Hea Kim,
Ka-Won Kang,
Byung-Hyun Lee,
Young Park,
Hwa Jung Sung,
Byung-Soo Kim

Affiliations

Ji-Hea Kim: Institute of Stem Cell Research, Korea University College of Medicine, Seoul, South Korea; Department of Biomedical and Science, Graduate School of Medicine, Korea University, Seoul, South Korea
Ka-Won Kang: Department of Internal Medicine, Korea University Medical School Hospital, Seoul, South Korea
Byung-Hyun Lee: Department of Internal Medicine, Korea University Medical School Hospital, Seoul, South Korea
Young Park: Department of Internal Medicine, Korea University Medical School Hospital, Seoul, South Korea
Hwa Jung Sung: Department of Internal Medicine, Korea University Medical School Hospital, Seoul, South Korea
Byung-Soo Kim: Institute of Stem Cell Research, Korea University College of Medicine, Seoul, South Korea; Department of Biomedical and Science, Graduate School of Medicine, Korea University, Seoul, South Korea; Department of Internal Medicine, Korea University Medical School Hospital, Seoul, South Korea; Corresponding author.

Journal volume & issue: Vol. 60
p. 102668

Abstract

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Chronic lymphocytic leukemia (CLL) is a type of blood cancer caused by the abnormal accumulation of malignant plasma cells. In this study, we generated CLL iPSCs (KUMi004-a) using the Sendai virus, confirming pluripotency. Also, it can differentiate into three primary germ layers. We expect this cell line could be helpful to understand the pathology of CLL.

Published in Stem Cell Research

ISSN: 1873-5061 (Print); 1876-7753 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Biology (General)
Website: https://www.journals.elsevier.com/stem-cell-research

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