BMJ Open Respiratory Research (Nov 2021)
Understanding the burden of interstitial lung disease post-COVID-19: the UK Interstitial Lung Disease-Long COVID Study (UKILD-Long COVID)
- R Gisli Jenkins,
- A John Simpson,
- Jennifer K Quint,
- Nicholas D Weatherley,
- Guilhem Collier,
- Jim M Wild,
- David R Thickett,
- Shaney L Barratt,
- Puja Mehta,
- Nazia Chaudhuri,
- Ling-Pei Ho,
- Lisa G Spencer,
- John F Blaikley,
- Fasihul Khan,
- Iain Stewart,
- John Kenneth Baillie,
- Rod Lawson,
- Simon R Johnson,
- Paul Beirne,
- Mark Spears,
- Laura Fabbri,
- Joseph Jacob,
- Fergus V Gleeson,
- Mark G Jones,
- Bibek Gooptu,
- Rachel C Chambers,
- Philip L Molyneaux,
- Peter M George,
- Michael A Gibbons,
- Emma K Denneny,
- Melissa Heightman,
- Toby E Hillman,
- Joanna C Porter,
- Manuela Platé,
- Stephen M Bianchi,
- Chris E Brightling,
- Richard James Allen,
- Annemarie Docherty,
- Jane A Mitchell,
- Ian P Hall,
- Jonathan Brooke,
- Louise V Wain,
- Malcolm Semple,
- Raminder Aul,
- Neil A Hanley,
- Krisnah Poinasamy,
- Pilar Rivera-Ortega,
- DJF Smith,
- Stefan C Stanel,
- A A Roger Thompson,
- Simon LF Walsh,
- Mark Everard Weeks,
- Dan G Wootton,
- Karen Piper Hanley
Affiliations
- R Gisli Jenkins
- Interstitial Lung Disease Unit, Royal Brompton & Harefield Hospitals, London, UK
- A John Simpson
- Newcastle University, Newcastle upon Tyne, UK
- Jennifer K Quint
- 8 NHLI, Imperial College London, London, London, UK
- Nicholas D Weatherley
- Department of Infection, Immunity and Cardiovascular Disease, The University of Sheffield, Sheffield, UK
- Guilhem Collier
- Department of Infection, Immunity and Cardiovascular Disease, The University of Sheffield, Sheffield, UK
- Jim M Wild
- 1Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK
- David R Thickett
- Birmingham Acute Care Research, University of Birmingham College of Medical and Dental Sciences, Birmingham, UK
- Shaney L Barratt
- Bristol Interstitial Lung Disease Service, North Bristol NHS Trust, Bristol, UK
- Puja Mehta
- 26 Centre for Inflammation and Tissue Repair, UCL Respiratory Division of Medicine, University College London Hospitals NHS Foundation Trust, London, UK
- Nazia Chaudhuri
- University of Ulster Faculty of Life and Health Sciences, Londonderry, UK
- Ling-Pei Ho
- MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, Oxford, UK
- Lisa G Spencer
- Liverpool Interstitial Lung Disease Service, Aintree Hospital, Liverpool University Hospitals NHS Foundation Trust Library and Knowledge Service, Liverpool, UK
- John F Blaikley
- Manchester Academic Health Science Centre, Manchester University NHS Foundation Trust, Manchester, UK
- Fasihul Khan
- Respiratory Medicine, University of Nottingham, Clinical Sciences Building, Nottingham City Hospital, Hucknall Road, Nottingham, UK
- Iain Stewart
- National Heart & Lung Institute, Imperial College London, London, UK
- John Kenneth Baillie
- Roslin Institute, University of Edinburgh, Midlothian, UK
- Rod Lawson
- Academic Department of Respiratory Medicine, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK
- Simon R Johnson
- Division of Respiratory Medicine and NIHR Biomedical Research Centre and National Centre for LAM, Nottingham Unioversity NHS Trust, Nottingham UK, University of Nottingham, Nottingham, UK
- Paul Beirne
- Respiratory Medicine, Leeds Teaching Hospitals NHS Trust, Leeds, UK
- Mark Spears
- Respiratory Medicine, Perth Royal Infirmary, NHS Tayside, Perth, UK
- Laura Fabbri
- National Heart and Lung Institute, Imperial College London Department of Medicine, London, UK
- Joseph Jacob
- 6 Centre for Medical Imaging and Computing, University College London, London, UK
- Fergus V Gleeson
- Departments of Radiology and Nuclear Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford, UK
- Mark G Jones
- Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK
- Bibek Gooptu
- Department of Molecular and Cell Biology, University of Leicester, Leicester, UK
- Rachel C Chambers
- Centre for Inflammation and Tissue Repair, UCL Respiratory, University College London, London, UK
- Philip L Molyneaux
- Interstitial Lung Disease Unit, Department of Respiratory Medicine, Royal Brompton and Harefield NHS Foundation Trust, London, UK
- Peter M George
- Interstitial Lung Disease Unit, Royal Brompton and Harefield NHS Foundation Trust, London, UK
- Michael A Gibbons
- Respiratory Medicine, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK
- Emma K Denneny
- Centre for Inflammation and Tissue Repair, UCL Respiratory, University College London, London, UK
- Melissa Heightman
- 5 University College London Hospitals NHS Foundation Trust, London, UK
- Toby E Hillman
- University College London Hospitals NHS Foundation Trust, London, UK
- Joanna C Porter
- 4 ILD Centre, University College London Hospital, London, UK
- Manuela Platé
- Centre for Inflammation and Tissue Repair, UCL Respiratory, University College London, London, UK
- Stephen M Bianchi
- Academic Department of Respiratory Medicine, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK
- Chris E Brightling
- Department of Respiratory Sciences, University of Leicester, Leicester, UK
- Richard James Allen
- Department of Health Sciences, University of Leicester, Leicester, UK
- Annemarie Docherty
- Usher Institute, The University of Edinburgh, Edinburgh, UK
- Jane A Mitchell
- National Heart and Lung Institute, Imperial College London, London, UK
- Ian P Hall
- Queen`s Medical Centre, Nottingham, UK
- Jonathan Brooke
- Department of Respiratory Medicine, Nottingham University Hospitals NHS Trust, Nottingham, UK
- Louise V Wain
- 1 The Institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK
- Malcolm Semple
- Child Health, University of Liverpool, Liverpool, UK
- Raminder Aul
- Respiratory Medicine, St Georges Hospital NHS Foundation Trust, London, UK
- Neil A Hanley
- Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK
- Krisnah Poinasamy
- Asthma and Lung UK, London, UK
- Pilar Rivera-Ortega
- Interstitial Lung Disease Unit, Respiratory Medicine, Manchester University NHS Foundation Trust, Manchester, UK
- DJF Smith
- National Heart and Lung Institute, Imperial College London, London, UK
- Stefan C Stanel
- Respiratory Department, University Hospital of South Manchester NHS Foundation Trust, Manchester, UK
- A A Roger Thompson
- Department of Infection, Immunity and Cardiovascular Disease, The University of Sheffield, Sheffield, UK
- Simon LF Walsh
- National Heart and Lung Institute, Imperial College London, London, UK
- Mark Everard Weeks
- National Heart and Lung Institute, Imperial College London, London, UK
- Dan G Wootton
- 1 Department of Clinical Infection, Microbiology and Immunology (CIMI), University of Liverpool, Liverpool, UK
- Karen Piper Hanley
- Division of Diabetes, Endocrinology & Gastroenterology, The University of Manchester, Manchester, UK
- DOI
- https://doi.org/10.1136/bmjresp-2021-001049
- Journal volume & issue
-
Vol. 8,
no. 1
Abstract
Introduction The COVID-19 pandemic has led to over 100 million cases worldwide. The UK has had over 4 million cases, 400 000 hospital admissions and 100 000 deaths. Many patients with COVID-19 suffer long-term symptoms, predominantly breathlessness and fatigue whether hospitalised or not. Early data suggest potentially severe long-term consequence of COVID-19 is development of long COVID-19-related interstitial lung disease (LC-ILD).Methods and analysis The UK Interstitial Lung Disease Consortium (UKILD) will undertake longitudinal observational studies of patients with suspected ILD following COVID-19. The primary objective is to determine ILD prevalence at 12 months following infection and whether clinically severe infection correlates with severity of ILD. Secondary objectives will determine the clinical, genetic, epigenetic and biochemical factors that determine the trajectory of recovery or progression of ILD. Data will be obtained through linkage to the Post-Hospitalisation COVID platform study and community studies. Additional substudies will conduct deep phenotyping. The Xenon MRI investigation of Alveolar dysfunction Substudy will conduct longitudinal xenon alveolar gas transfer and proton perfusion MRI. The POST COVID-19 interstitial lung DiseasE substudy will conduct clinically indicated bronchoalveolar lavage with matched whole blood sampling. Assessments include exploratory single cell RNA and lung microbiomics analysis, gene expression and epigenetic assessment.Ethics and dissemination All contributing studies have been granted appropriate ethical approvals. Results from this study will be disseminated through peer-reviewed journals.Conclusion This study will ensure the extent and consequences of LC-ILD are established and enable strategies to mitigate progression of LC-ILD.
