Advances in molecular mechanism of bladder detrusor dysfunction

Abstract

Bladder outlet obstruction (BOO) increases micturition resistance and prolongs the duration of intravesical hypertension. The intravesical pressure overloads the hydrostatic pressure and mechanical tensile force of detrusor,which triggers the cascade reaction of muscle cells starting from mechanical tension stress, hypoxia and ischemia-reperfusion injury (IRI), leading to changes in intracellular metabolism and reconstruction of extracellular matrix.The change of interstitial components is irreversible injury, and there is no effective treatment measures in the decompensation stage. At present, the exact pathogenesis is not completely clear. The study on the pathogenesis of BOO may support early detection of obstructive dysuria, which is of great significance for clinical treatment.

Keywords

• bladder outlet obstruction|bladder remodeling|urothelial fibrosis|smooth muscle