A spectrophotometrical analitic method elaboration for tinidazole’s quantity determination from tablets

Abstract

The main inconvenience of analytical determination of Tinidazole in pharmaceutical formulations consists in presence of ingredients, frequently with unknown identity. In order to overcome the complications of methods based on selective separations, a spectrophotometrical method for Tinidazole assay was performed and tested. By appropriate derivatization of the analythe, a photometrically estimable Schiff base is obtained, with absorptionin the visible region where the interference of ingredients is negligible. The linearity of analytic signal was checked out in methanol solution in the 2–14 mg/l concentration domain. The method exhibit a good reproducibility: in a 8-fold repetition the main standard deviation is 0.38 % of the average of individual values.

Keywords

• tinidazole
• antiparazitic agent
• visible spectrophotometry
• HPLC