Myonuclear content regulates cell size with similar scaling properties in mice and humans

Kenth-Arne Hansson; Einar Eftestøl; Jo C. Bruusgaard; Inga Juvkam; Alyssa W. Cramer; Anders Malthe-Sørenssen; Douglas P. Millay; Kristian Gundersen

doi:10.1038/s41467-020-20057-8

Nature Communications (Dec 2020)

Myonuclear content regulates cell size with similar scaling properties in mice and humans

Kenth-Arne Hansson,
Einar Eftestøl,
Jo C. Bruusgaard,
Inga Juvkam,
Alyssa W. Cramer,
Anders Malthe-Sørenssen,
Douglas P. Millay,
Kristian Gundersen

Affiliations

Kenth-Arne Hansson: Department of Biosciences, University of Oslo
Einar Eftestøl: Department of Biosciences, University of Oslo
Jo C. Bruusgaard: Department of Biosciences, University of Oslo
Inga Juvkam: Department of Biosciences, University of Oslo
Alyssa W. Cramer: Division of Molecular Cardiovascular Biology, Cincinnati Children’s Hospital Medical Center
Anders Malthe-Sørenssen: Center for Integrative Neuroplasticity, Department of Biosciences, University of Oslo
Douglas P. Millay: Division of Molecular Cardiovascular Biology, Cincinnati Children’s Hospital Medical Center
Kristian Gundersen: Department of Biosciences, University of Oslo

DOI: https://doi.org/10.1038/s41467-020-20057-8
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 14

Abstract

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Muscle fibers are the largest cells in the body and contain less DNA per unit volume than other cells even if they have multiple nuclei. Here, the authors show that the number of nuclei regulates the cell size with similar scaling properties in mice and humans.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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