Nature Communications (Feb 2018)

UFD-2 is an adaptor-assisted E3 ligase targeting unfolded proteins

  • Doris Hellerschmied,
  • Max Roessler,
  • Anita Lehner,
  • Linn Gazda,
  • Karel Stejskal,
  • Richard Imre,
  • Karl Mechtler,
  • Alexander Dammermann,
  • Tim Clausen

DOI
https://doi.org/10.1038/s41467-018-02924-7
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 15

Abstract

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The U-box ubiquitin ligase UFD-2 is one of the most abundant components of the ubiquitin proteasome system in muscle cells. Here the authors perform in vitro and in vivo experiments and show that UFD-2 has E3 ligase activity and that it ubiquitinates unfolded myosin using the C. elegans myosin chaperone UNC-45 as an adaptor protein.