Chemical Constituents with Anti-Proliferative Activity on Pulmonary Arterial Smooth Muscle Cells from the Roots of <i>Anthriscus sylvestris</i> (L.) Hoffm.
Yanling Liu,
Yangang Cao,
Yajuan Zheng,
Ying Niu,
Lan Chen,
Xu Chen,
Xinyi Ma,
Xiangda Li,
Xiaoke Zheng,
Weisheng Feng
Affiliations
Yanling Liu
School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China
Yangang Cao
School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China
Yajuan Zheng
School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China
Ying Niu
School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China
Lan Chen
School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China
Xu Chen
School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China
Xinyi Ma
School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China
Xiangda Li
School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China
Xiaoke Zheng
School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China
Weisheng Feng
School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China
A chemical investigation of Anthriscus sylvestris roots led to the isolation and characterization of two new nitrogen-containing phenylpropanoids (1–2) and two new phenol glycosides (8–9), along with fifteen known analogues. Structure elucidation was based on HRESIMS, 1D and 2D NMR spectroscopy, and electronic circular dichroism (ECD). In addition, compounds 3, 6, 9–10, 12, and 17 exhibited inhibitory effects against the abnormal proliferation of pulmonary arterial smooth muscle cells with IC50 values ranging from 10.7 ± 0.6 to 57.1 ± 1.1 μM.
