PLoS ONE (Jan 2014)

Intake of fruit juice and incidence of type 2 diabetes: a systematic review and meta-analysis.

  • Bo Xi,
  • Shuangshuang Li,
  • Zhaolu Liu,
  • Huan Tian,
  • Xiuxiu Yin,
  • Pengcheng Huai,
  • Weihong Tang,
  • Donghao Zhou,
  • Lyn M Steffen

DOI
https://doi.org/10.1371/journal.pone.0093471
Journal volume & issue
Vol. 9, no. 3
p. e93471

Abstract

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BackgroundSeveral prospective studies have been conducted to examine the relationship between fruit juice intake and risk of incident type 2 diabetes, but results have been mixed. In the present study, we aimed to estimate the association between fruit juice intake and risk of type 2 diabetes.MethodsPubMed and Embase databases were searched up to December 2013. All prospective cohort studies of fruit juice intake with risk of type 2 diabetes were included. The pooled relative risks (RRs) with 95% confidence intervals (CIs) for highest vs. lowest category of fruit juice intake were estimated using a random-effects model.ResultsA total of four studies (191,686 participants, including 12,375 with type 2 diabetes) investigated the association between sugar-sweetened fruit juice and risk of incident type 2 diabetes, and four studies (137,663 participants and 4,906 cases) investigated the association between 100% fruit juice and risk of incident type 2 diabetes. A higher intake of sugar-sweetened fruit juice was significantly associated with risk of type 2 diabetes (RR = 1.28, 95%CI = 1.04-1.59, p = 0.02), while intake of 100% fruit juice was not associated with risk of developing type 2 diabetes (RR = 1.03, 95% CI = 0.91-1.18, p = 0.62).ConclusionsOur findings support dietary recommendations to limit sugar-sweetened beverages, such as fruit juice with added sugar, to prevent the development of type 2 diabetes.