ADP-Ribosylation Factor Family of Small GTP-Binding Proteins: Their Membrane Recruitment, Activation, Crosstalk and Functions

Tiantian Li; Yusong Guo; Yusong Guo; Yusong Guo

doi:10.3389/fcell.2022.813353

Frontiers in Cell and Developmental Biology (Feb 2022)

ADP-Ribosylation Factor Family of Small GTP-Binding Proteins: Their Membrane Recruitment, Activation, Crosstalk and Functions

Tiantian Li,
Yusong Guo,
Yusong Guo,
Yusong Guo

Affiliations

Tiantian Li: Division of Life Science and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Kowloon, Hong Kong SAR, China
Yusong Guo: Division of Life Science and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Kowloon, Hong Kong SAR, China
Yusong Guo: Hong Kong University of Science and Technology, Shenzhen Research Institute, Shenzhen, China
Yusong Guo: Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou, China

DOI: https://doi.org/10.3389/fcell.2022.813353
Journal volume & issue: Vol. 10

Abstract

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Members of the ADP-ribosylation factor (ARF) family of guanine-nucleotide binding proteins play critical roles in various cellular processes, especially in regulating the secretory, and endocytic pathways. The fidelity of intracellular vesicular trafficking depends on proper activations and precise subcellular distributions of ARF family proteins regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Here we review recent progress in understanding the membrane recruitment, activation, crosstalk, and functions of ARF family proteins.

Published in Frontiers in Cell and Developmental Biology

ISSN: 2296-634X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: https://www.frontiersin.org/journals/cell-and-developmental-biology

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