Nature Communications (Sep 2020)

An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction

  • Leo Hanke,
  • Laura Vidakovics Perez,
  • Daniel J. Sheward,
  • Hrishikesh Das,
  • Tim Schulte,
  • Ainhoa Moliner-Morro,
  • Martin Corcoran,
  • Adnane Achour,
  • Gunilla B. Karlsson Hedestam,
  • B. Martin Hällberg,
  • Ben Murrell,
  • Gerald M. McInerney

DOI
https://doi.org/10.1038/s41467-020-18174-5
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 9

Abstract

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Here, Hanke et al. immunize an alpaca with SARS-CoV-2 spike protein domains and identify a nanobody that binds the receptor binding domain of spike in both the up and down conformations and sterically hinders ACE2 engagement.