Nature Communications (Oct 2020)
Chromatin accessibility landscape and regulatory network of high-altitude hypoxia adaptation
- Jingxue Xin,
- Hui Zhang,
- Yaoxi He,
- Zhana Duren,
- Caijuan Bai,
- Lang Chen,
- Xin Luo,
- Dong-Sheng Yan,
- Chaoyu Zhang,
- Xiang Zhu,
- Qiuyue Yuan,
- Zhanying Feng,
- Chaoying Cui,
- Xuebin Qi,
- Ouzhuluobu,
- Wing Hung Wong,
- Yong Wang,
- Bing Su
Affiliations
- Jingxue Xin
- State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences
- Hui Zhang
- State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences
- Yaoxi He
- State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences
- Zhana Duren
- Departments of Statistics, Stanford University
- Caijuan Bai
- High Altitude Medical Research Center, School of Medicine, Tibetan University
- Lang Chen
- CEMS, NCMIS, MDIS, Academy of Mathematics and Systems Science, Chinese Academy of Sciences
- Xin Luo
- State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences
- Dong-Sheng Yan
- School of Mathematical Science, Inner Mongolia University
- Chaoyu Zhang
- CEMS, NCMIS, MDIS, Academy of Mathematics and Systems Science, Chinese Academy of Sciences
- Xiang Zhu
- Departments of Statistics, Stanford University
- Qiuyue Yuan
- CEMS, NCMIS, MDIS, Academy of Mathematics and Systems Science, Chinese Academy of Sciences
- Zhanying Feng
- CEMS, NCMIS, MDIS, Academy of Mathematics and Systems Science, Chinese Academy of Sciences
- Chaoying Cui
- High Altitude Medical Research Center, School of Medicine, Tibetan University
- Xuebin Qi
- State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences
- Ouzhuluobu
- High Altitude Medical Research Center, School of Medicine, Tibetan University
- Wing Hung Wong
- Bio-X Program, Stanford University
- Yong Wang
- CEMS, NCMIS, MDIS, Academy of Mathematics and Systems Science, Chinese Academy of Sciences
- Bing Su
- State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences
- DOI
- https://doi.org/10.1038/s41467-020-18638-8
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 20
Abstract
Tibetan adaptation to the high-altitude environment represents a case of natural selection during recent human evolution. Here the authors investigated the chromatin and transcriptional landscape of umbilical endothelial cells from Tibetan and Han Chinese donors and provide genome-wide characterization of the hypoxia regulatory network associated high-altitude adaptation.
