5-Methyl-1-phenyl-3-(thieno[2,3-<i>d</i>]pyrimidin-4-yl)chromeno[4,3-<i>d</i>]pyrazolo[3,4-<i>b</i>]pyridin-6(3<i>H</i>)-one

Abstract

A chromeno[4,3-d]pyrazolo[3,4-b]pyridinone derivative 3 bearing thieno[2,3-d]pyrimidine moiety, 5-methyl-1-phenyl-3-(thieno[2,3-d]pyrimidin-4-yl)chromeno[4,3-d]pyrazolo[3,4-b]pyridin-6(3H)-one, was efficiently prepared in 75% yield by the reaction of 3-phenyl-1-(thieno[2,3-d]pyrimidin-4-yl)-1H-pyrazol-5-amine 1 with 3-acetyl-2H-chromen-2-one 2 in the presence of FeCl3-SiO2 as a catalyst in refluxing ethanol for 6 h. The structure of the new synthesized compound was characterized by 1H-, 13C- NMR, IR spectroscopy, mass-spectrometry, and elemental analysis.

Keywords

• coumarin
• pyrazolo[3,4-<i>b</i>]pyridine
• thieno[2,3-<i>d</i>]pyrimidine
• FeCl₃-SiO₂