Helicobacter pylori in the Indonesian Malay’s descendants might be imported from other ethnicities
Ari Fahrial Syam,
Langgeng Agung Waskito,
Yudith Annisa Ayu Rezkitha,
Rentha Monica Simamora,
Fauzi Yusuf,
Kanserina Esthera Danchi,
Ahmad Fuad Bakry,
Arnelis,
Erwin Mulya,
Gontar Alamsyah Siregar,
Titong Sugihartono,
Hasan Maulahela,
Dalla Doohan,
Muhammad Miftahussurur,
Yoshio Yamaoka
Affiliations
Ari Fahrial Syam
Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine-Cipto Mangunkusumo Teaching Hospital, University of Indonesia
Langgeng Agung Waskito
Faculty of Medicine, Universitas Airlangga
Yudith Annisa Ayu Rezkitha
Institute of Tropical Disease, Universitas Airlangga
Rentha Monica Simamora
Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga
Fauzi Yusuf
Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine, Dr. Zainoel Abidin General Hospital, Universitas Syiah Kuala
Kanserina Esthera Danchi
Department of Internal Medicine, Dr. M Thomsen Nias Gunungsitoli General Hospital
Ahmad Fuad Bakry
Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine, Sriwijaya University
Arnelis
Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, Andalas University
Erwin Mulya
Department of Internal Medicine, Cimacan General Hospital
Gontar Alamsyah Siregar
Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine, University of Sumatera Utara
Titong Sugihartono
Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine-Dr Soetomo Teaching Hospital, Universitas Airlangga
Hasan Maulahela
Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine-Cipto Mangunkusumo Teaching Hospital, University of Indonesia
Dalla Doohan
Faculty of Medicine, Universitas Airlangga
Muhammad Miftahussurur
Institute of Tropical Disease, Universitas Airlangga
Yoshio Yamaoka
Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine
Abstract Background Even though the incidence of H. pylori infection among Malays in the Malay Peninsula is low, we observed a high H. pylori prevalence in Sumatra, which is the main residence of Indonesian Malays. H. pylori prevalence among Indonesian Malay descendants was investigated. Results Using a combination of five tests, 232 recruited participants were tested for H- pylori and participants were considered positive if at least one test positive. The results showed that the overall H. pylori prevalence was 17.2%. Participants were then categorized into Malay (Aceh, Malay, and Minang), Java (Javanese and Sundanese), Nias, and Bataknese groups. The prevalence of H. pylori was very low among the Malay group (2.8%) and no H. pylori was observed among the Aceh. Similarly, no H. pylori was observed among the Java group. However, the prevalence of H. pylori was high among the Bataknese (52.2%) and moderate among the Nias (6.1%). Multilocus sequence typing showed that H. pylori in Indonesian Malays classified as hpEastAsia with a subpopulation of hspMaori, suggesting that the isolated H. pylori were not a specific Malays H. pylori. Conclusions Even though the ethnic groups live together as a community, we observed an extremely low H. pylori infection rate among Indonesian Malay descendants with no specific Indonesian Malay H. pylori. The results suggest that H. pylori was not originally among these groups and H. pylori was imported from other ethnic groups.
