Research progress on the role of forkhead box protein M1 in brain glioma

Abstract

Glioma is the most common primary tumor found in central nervous system of adult patients. The forkhead box protein M1 (FOXM1) is a member of the forkhead box transcription factor family, which can regulate Wnt/β-Catenin, Akt/FOXM1, p53 pathways and their own post-translational modification processes promote the malignant proliferation, migration, and invasion of glioma. These results of research provide new theoretical basis and therapeutic targets for the clinical treatment of glioma.

Keywords

• forkhead box protein m1(foxm1)|glioma|wnt/β-catenin|akt/foxm1|p53 pathway