Nature Communications (Jul 2016)

The landscape of chromosomal aberrations in breast cancer mouse models reveals driver-specific routes to tumorigenesis

  • Uri Ben-David,
  • Gavin Ha,
  • Prasidda Khadka,
  • Xin Jin,
  • Bang Wong,
  • Lude Franke,
  • Todd R. Golub

DOI
https://doi.org/10.1038/ncomms12160
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 13

Abstract

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Genetically engineered mouse models of cancer are useful in identifying oncogenes and tumour suppressors. Here, the authors use gene expression profiles to generate a catalogue of copy number aberrations in 45 mouse models, and compare mouse and human tumours to identify additional drivers of tumorigenesis.