Improving the early diagnosis and clinical outcomes of shock patients via laser speckle contrast imaging assessment of peripheral hemodynamics
Meng-Che Hsieh,
Jin-Jia Hu,
Yan-Ren Lin,
Shih-Yu Li,
Pei-You Hsieh,
Congo Tak Shing Ching,
Lun-De Liao
Affiliations
Meng-Che Hsieh
Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, 35, Keyan Road, Zhunan Town, Miaoli County 350, Taiwan; Doctoral Program in Tissue Engineering and Regenerative Medicine, National Chung Hsing University, 145, Xingda Road, South District, Taichung City 402, Taiwan
Jin-Jia Hu
Department of Mechanical Engineering, National Yang Ming Chiao Tung University, No. 1001, Daxue Rd. East Dist., Hsinchu City 300093, Taiwan; Corresponding author
Yan-Ren Lin
Department of Emergency and Critical Care Medicine, Changhua Christian Hospital, Changhua, Taiwan
Shih-Yu Li
Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, 35, Keyan Road, Zhunan Town, Miaoli County 350, Taiwan; Department of Mechanical Engineering, National Yang Ming Chiao Tung University, No. 1001, Daxue Rd. East Dist., Hsinchu City 300093, Taiwan
Pei-You Hsieh
Department of Emergency and Critical Care Medicine, Changhua Christian Hospital, Changhua, Taiwan
Congo Tak Shing Ching
Doctoral Program in Tissue Engineering and Regenerative Medicine, National Chung Hsing University, 145, Xingda Road, South District, Taichung City 402, Taiwan; Graduate Institute of Biomedical Engineering, National Chung Hsing University, 145, Xingda Road, South District, Taichung City 402, Taiwan; Department of Electrical Engineering, National Chi Nan University, Puli Township 54561, Taiwan; International Doctoral Program in Agriculture, National Chung Hsing University, Taichung 402, Taiwan; Advanced Plant and Food Crop Biotechnology Center, National Chung Hsing University, Taichung 402, Taiwan
Lun-De Liao
Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, 35, Keyan Road, Zhunan Town, Miaoli County 350, Taiwan; Doctoral Program in Tissue Engineering and Regenerative Medicine, National Chung Hsing University, 145, Xingda Road, South District, Taichung City 402, Taiwan; Corresponding author
Summary: Shock is defined as a critical circulatory failure that requires prompt diagnosis to optimize patient outcomes. Traditional diagnostic methods have limitations, including contact-based measurements, high costs, and lengthy procedures. The study evaluated the efficacy of laser speckle contrast imaging (LSCI), a noncontact technique, for assessing peripheral hemodynamics in shock patients. Results showed that LSCI accurately captured dynamic changes in blood flow, revealing early indicators of shock. ROI diff and ROI diff/ROI2 values significantly differed between shock patients and healthy controls. Spearman’s correlation analysis revealed associations between ROI diff and key physiological parameters, such as blood pressure and heart rate. ROC analysis revealed that ROI diff and ROI diff/ROI2 had strong accuracy (72.5% and 82.5%, respectively) for detecting shock. Additionally, LSCI reduced testing time by over 50%, offering faster assessments. These findings demonstrate the potential of LSCI to improve diagnosis and management of shock, especially in complex clinical environments.
