Common vole (Microtus arvalis Pallas, 1778) is one of the economically important rodents, especially in winter wheat. Multiple deratizations were done on the locality of Kneževo, “Belje” d.d., in winter wheat with different tillage treatments. It was done in the period of December 1999 - March 2000. Brodilon rodenticide was used in dosages 10 g/ hole. The presence of meadow mouse before deratization was in 2nd and 3rd category. After deratizations, declining trend was noticed in population dynamics. In standard tillage treatment the efficacy was 97%; in treatment with multiple disking the efficacy was 89.25%; in soil loosening + disking the efficacy was 87.65%; in one-pass disking it was 94.05% while in no tillage treatment efficacy was 80.34%. The average efficacy was 91.99%. Multiple deratizations and reduced tillage can significantly reduce the population dynamics of meadow mouse.