Nature Communications (Nov 2018)

Synthetic RNA-based logic computation in mammalian cells

  • Satoshi Matsuura,
  • Hiroki Ono,
  • Shunsuke Kawasaki,
  • Yi Kuang,
  • Yoshihiko Fujita,
  • Hirohide Saito

DOI
https://doi.org/10.1038/s41467-018-07181-2
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 8

Abstract

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The construction of complex RNA-delivered genetic circuits in mammalian cells is challenging, though offers advantages over DNA circuits in clinical use. Here the authors construct a set of logic gates that respond to multiple miRNAs and demonstrate an apoptosis-regulatory AND gate.