Journal of Clinical and Diagnostic Research (Dec 2019)

Oxidised LDL Cholesterol (Ox-LDL-C) and Ox-LDL-C/HDL Cholesterol (HDL-C) Ratio in Acute Coronary Syndrome Patients versus Chronic Coronary Artery Disease Patients on Statin Treatment

  • Sumina Cheriyan,
  • Deepti Girija Nandakumaran,
  • D Dinesh Roy,
  • Jaideep Mahendra,
  • Viji Krishnan

DOI
https://doi.org/10.7860/JCDR/2019/42447.13388
Journal volume & issue
Vol. 13, no. 12
pp. BC14 – BC17

Abstract

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Introduction: Oxidised Low Density Lipoprotein Cholesterol (Ox-LDL-C) and High Density Lipoprotein Cholesterol (HDL-C) have antagonistic action in the development of atherosclerotic cardiovascular disease. Use of statins reduces cardiovascular risk by reducing LDL-C levels and also by increasing HDL-C. No systematic studies were carried out to study the role of HDL-C as an antioxidant and its effect in decreasing Ox-LDL-C. Aim: To compare the values of Ox-LDL-C/HDL-C in patients with chronic Coronary Artery Disease (CAD) and patients with Acute Coronary Syndrome (ACS) and to evaluate the levels of Ox-LDL-C and Ox LDL-C/HDL-C ratio in patients treated with the two different statins. Materials and Methods: In this cross-sectional study 30 patients with ACS and 30 patients with chronic CAD on rosuvastatin or atorvastatin were included in the study. Apparently normal 27 age and sex-matched controls without CAD was included in the study. Lipid profile was estimated using fully auto analyser and Ox-LDL-C was estimated using ELISA kits. Statistical analysis was done using SPSS version 16 software. A p-value of <0.05 was considered as statistically significant. Results: Hypertension and diabetes were found to be significantly associated with CAD (p-value 0.03). There was significant correlation between total cholesterol, triglycerides, with CAD. The levels of triglycerides, Ox-LDL-C and Ox-LDL-C/ HDL-C were significantly higher (p<0.05) in ACS patients compared to chronic CAD and normal. Total cholesterol and LDL-C were lower in chronic CAD patients on atorvastatin treatment compared to patients on rosuvastatin treatment. Conclusion: Ox-LDL-C/HDL-C ratio is a better predictor of acute coronary events. In addition to lipid lowering action, statins have pleiotropic benefits including prevention of LDL oxidation.

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