Nature Communications (Jan 2016)
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function
- Cristian Pattaro,
- Alexander Teumer,
- Mathias Gorski,
- Audrey Y. Chu,
- Man Li,
- Vladan Mijatovic,
- Maija Garnaas,
- Adrienne Tin,
- Rossella Sorice,
- Yong Li,
- Daniel Taliun,
- Matthias Olden,
- Meredith Foster,
- Qiong Yang,
- Ming-Huei Chen,
- Tune H. Pers,
- Andrew D. Johnson,
- Yi-An Ko,
- Christian Fuchsberger,
- Bamidele Tayo,
- Michael Nalls,
- Mary F. Feitosa,
- Aaron Isaacs,
- Abbas Dehghan,
- Pio d’Adamo,
- Adebowale Adeyemo,
- Aida Karina Dieffenbach,
- Alan B. Zonderman,
- Ilja M. Nolte,
- Peter J. van der Most,
- Alan F. Wright,
- Alan R. Shuldiner,
- Alanna C. Morrison,
- Albert Hofman,
- Albert V. Smith,
- Albert W. Dreisbach,
- Andre Franke,
- Andre G. Uitterlinden,
- Andres Metspalu,
- Anke Tonjes,
- Antonio Lupo,
- Antonietta Robino,
- Åsa Johansson,
- Ayse Demirkan,
- Barbara Kollerits,
- Barry I. Freedman,
- Belen Ponte,
- Ben A. Oostra,
- Bernhard Paulweber,
- Bernhard K. Krämer,
- Braxton D. Mitchell,
- Brendan M. Buckley,
- Carmen A. Peralta,
- Caroline Hayward,
- Catherine Helmer,
- Charles N. Rotimi,
- Christian M. Shaffer,
- Christian Müller,
- Cinzia Sala,
- Cornelia M. van Duijn,
- Aude Saint-Pierre,
- Daniel Ackermann,
- Daniel Shriner,
- Daniela Ruggiero,
- Daniela Toniolo,
- Yingchang Lu,
- Daniele Cusi,
- Darina Czamara,
- David Ellinghaus,
- David S. Siscovick,
- Douglas Ruderfer,
- Christian Gieger,
- Harald Grallert,
- Elena Rochtchina,
- Elizabeth J. Atkinson,
- Elizabeth G. Holliday,
- Eric Boerwinkle,
- Erika Salvi,
- Erwin P. Bottinger,
- Federico Murgia,
- Fernando Rivadeneira,
- Florian Ernst,
- Florian Kronenberg,
- Frank B. Hu,
- Gerjan J. Navis,
- Gary C. Curhan,
- George B. Ehret,
- Georg Homuth,
- Stefan Coassin,
- Gian-Andri Thun,
- Giorgio Pistis,
- Giovanni Gambaro,
- Giovanni Malerba,
- Grant W. Montgomery,
- Gudny Eiriksdottir,
- Gunnar Jacobs,
- Guo Li,
- H-Erich Wichmann,
- Harry Campbell,
- Helena Schmidt,
- Henri Wallaschofski,
- Henry Völzke,
- Hermann Brenner,
- Heyo K. Kroemer,
- Holly Kramer,
- Honghuang Lin,
- I. Mateo Leach,
- Ian Ford,
- Idris Guessous,
- Igor Rudan,
- Inga Prokopenko,
- Ingrid Borecki,
- Iris M. Heid,
- Ivana Kolcic,
- Ivana Persico,
- J. Wouter Jukema,
- James F. Wilson,
- Janine F. Felix,
- Jasmin Divers,
- Jean-Charles Lambert,
- Jeanette M. Stafford,
- Jean-Michel Gaspoz,
- Jennifer A. Smith,
- Jessica D. Faul,
- Jie Jin Wang,
- Jingzhong Ding,
- Joel N. Hirschhorn,
- John Attia,
- John B. Whitfield,
- John Chalmers,
- Jorma Viikari,
- Josef Coresh,
- Joshua C. Denny,
- Juha Karjalainen,
- Jyotika K. Fernandes,
- Karlhans Endlich,
- Katja Butterbach,
- Keith L. Keene,
- Kurt Lohman,
- Laura Portas,
- Lenore J. Launer,
- Leo-Pekka Lyytikäinen,
- Loic Yengo,
- Lude Franke,
- Luigi Ferrucci,
- Lynda M. Rose,
- Lyudmyla Kedenko,
- Madhumathi Rao,
- Maksim Struchalin,
- Marcus E. Kleber,
- Margherita Cavalieri,
- Margot Haun,
- Marilyn C. Cornelis,
- Marina Ciullo,
- Mario Pirastu,
- Mariza de Andrade,
- Mark A. McEvoy,
- Mark Woodward,
- Martin Adam,
- Massimiliano Cocca,
- Matthias Nauck,
- Medea Imboden,
- Melanie Waldenberger,
- Menno Pruijm,
- Marie Metzger,
- Michael Stumvoll,
- Michele K. Evans,
- Michele M. Sale,
- Mika Kähönen,
- Mladen Boban,
- Murielle Bochud,
- Myriam Rheinberger,
- Niek Verweij,
- Nabila Bouatia-Naji,
- Nicholas G. Martin,
- Nick Hastie,
- Nicole Probst-Hensch,
- Nicole Soranzo,
- Olivier Devuyst,
- Olli Raitakari,
- Omri Gottesman,
- Oscar H. Franco,
- Ozren Polasek,
- Paolo Gasparini,
- Patricia B. Munroe,
- Paul M. Ridker,
- Paul Mitchell,
- Paul Muntner,
- Christa Meisinger,
- Johannes H. Smit,
- ICBP Consortium,
- AGEN Consortium,
- CARDIOGRAM,
- CHARGe-Heart Failure Group,
- ECHOGen Consortium,
- Peter Kovacs,
- Philipp S. Wild,
- Philippe Froguel,
- Rainer Rettig,
- Reedik Mägi,
- Reiner Biffar,
- Reinhold Schmidt,
- Rita P. S. Middelberg,
- Robert J. Carroll,
- Brenda W. Penninx,
- Rodney J. Scott,
- Ronit Katz,
- Sanaz Sedaghat,
- Sarah H. Wild,
- Sharon L. R. Kardia,
- Sheila Ulivi,
- Shih-Jen Hwang,
- Stefan Enroth,
- Stefan Kloiber,
- Stella Trompet,
- Benedicte Stengel,
- Stephen J. Hancock,
- Stephen T. Turner,
- Sylvia E. Rosas,
- Sylvia Stracke,
- Tamara B. Harris,
- Tanja Zeller,
- Tatijana Zemunik,
- Terho Lehtimäki,
- Thomas Illig,
- Thor Aspelund,
- Tiit Nikopensius,
- Tonu Esko,
- Toshiko Tanaka,
- Ulf Gyllensten,
- Uwe Völker,
- Valur Emilsson,
- Veronique Vitart,
- Ville Aalto,
- Vilmundur Gudnason,
- Vincent Chouraki,
- Wei-Min Chen,
- Wilmar Igl,
- Winfried März,
- Wolfgang Koenig,
- Wolfgang Lieb,
- Ruth J. F. Loos,
- Yongmei Liu,
- Harold Snieder,
- Peter P. Pramstaller,
- Afshin Parsa,
- Jeffrey R. O’Connell,
- Katalin Susztak,
- Pavel Hamet,
- Johanne Tremblay,
- Ian H. de Boer,
- Carsten A. Böger,
- Wolfram Goessling,
- Daniel I. Chasman,
- Anna Köttgen,
- W. H. Linda Kao,
- Caroline S. Fox
Affiliations
- Cristian Pattaro
- Center for Biomedicine, European Academy of Bozen/Bolzano (EURAC), affiliated to the University of Lübeck
- Alexander Teumer
- Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald
- Mathias Gorski
- Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg
- Audrey Y. Chu
- Preventive Medicine, Brigham and Women’s Hospital
- Man Li
- Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health
- Vladan Mijatovic
- Department of Life and Reproduction Sciences, University of Verona
- Maija Garnaas
- Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School
- Adrienne Tin
- Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health
- Rossella Sorice
- Institute of Genetics and Biophysics "Adriano Buzzati-Traverso"—CNR
- Yong Li
- Department of Internal Medicine IV, University Hospital Freiburg
- Daniel Taliun
- Center for Biomedicine, European Academy of Bozen/Bolzano (EURAC), affiliated to the University of Lübeck
- Matthias Olden
- Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg
- Meredith Foster
- Division of Nephrology/Tufts Evidence Practice Center, Tufts University School of Medicine, Tufts Medical Center
- Qiong Yang
- Department of Biostatistics, Boston University School of Public Health
- Ming-Huei Chen
- Department of Biostatistics, Boston University School of Public Health
- Tune H. Pers
- Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children’s Hospital
- Andrew D. Johnson
- NHLBI's Framingham Heart Study and the Center for Population Studies
- Yi-An Ko
- Renal Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania
- Christian Fuchsberger
- Center for Biomedicine, European Academy of Bozen/Bolzano (EURAC), affiliated to the University of Lübeck
- Bamidele Tayo
- Department of Public Health Sciences, Loyola Medical Center
- Michael Nalls
- Laboratory of Neurogenetics
- Mary F. Feitosa
- Division of Statistical Genomics, Washington University School of Medicine
- Aaron Isaacs
- Department of Epidemiology, Genetic Epidemiology Unit, Erasmus University Medical Center
- Abbas Dehghan
- Department of Epidemiology, Erasmus University Medical Center
- Pio d’Adamo
- Institute for Maternal and Child Health—IRCCS "Burlo Garofolo" and University of Trieste
- Adebowale Adeyemo
- Center for Research on Genomics and Global Health, National Human Genome Research Institute
- Aida Karina Dieffenbach
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ)
- Alan B. Zonderman
- Laboratory of Personality and Cognition, National Institute on Aging, National Institutes of Health, NIH Biomedical Center
- Ilja M. Nolte
- Department of Epidemiology, Unit of Genetic Epidemiology and Bioinformatics, University Medical Center Groningen
- Peter J. van der Most
- Department of Epidemiology, Unit of Genetic Epidemiology and Bioinformatics, University Medical Center Groningen
- Alan F. Wright
- MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
- Alan R. Shuldiner
- Department of Medicine, University of Maryland School of Medicine
- Alanna C. Morrison
- Human Genetics Center, University of Texas Health Science Center at Houston
- Albert Hofman
- Department of Epidemiology, Erasmus University Medical Center
- Albert V. Smith
- Icelandic Heart Association, Research Institute
- Albert W. Dreisbach
- Division of Nephrology, University of Mississippi
- Andre Franke
- Institute of Clinical Molecular Biology, Christian-Albrechts University of Kiel
- Andre G. Uitterlinden
- Department of Internal Medicine, Erasmus University Medical Center
- Andres Metspalu
- Estonian Genome Center of University of Tartu (EGCUT)
- Anke Tonjes
- Department of Medicine, University of Leipzig
- Antonio Lupo
- Division of Nephrology, Department of Medicine, University of Verona
- Antonietta Robino
- Institute for Maternal and Child Health—IRCCS "Burlo Garofolo" and University of Trieste
- Åsa Johansson
- Department of Immunology, Uppsala University, Genetics and Pathology, Biomedical Center, SciLifeLab, Uppsala University
- Ayse Demirkan
- Department of Epidemiology, Genetic Epidemiology Unit, Erasmus University Medical Center
- Barbara Kollerits
- Division of Genetic Epidemiology, Innsbruck Medical University
- Barry I. Freedman
- Internal Medicine Department, Wake Forest School of Medicine
- Belen Ponte
- Nephrology Division, Department of Specialties of Internal Medicine, Geneva University Hospital
- Ben A. Oostra
- Department of Clinical Genetics, Erasmus University Medical Center
- Bernhard Paulweber
- First Department of Internal Medicine, Paracelsus Medical University/Salzburger Landeskliniken
- Bernhard K. Krämer
- 5th Department of Medicine, University Medical Centre Mannheim, University of Heidelberg
- Braxton D. Mitchell
- Department of Medicine, University of Maryland School of Medicine
- Brendan M. Buckley
- Department of Pharmacology and Therapeutics, University College Cork, Clinical Investigations Building
- Carmen A. Peralta
- Division of Nephrology, University of California, San Francisco Medical School and San Francisco VA Medical Center
- Caroline Hayward
- MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
- Catherine Helmer
- INSERM, ISPED, Centre INSERM U897—Epidemiologie-Biostatistique
- Charles N. Rotimi
- Center for Research on Genomics and Global Health, National Human Genome Research Institute
- Christian M. Shaffer
- Vanderbilt University School of Medicine
- Christian Müller
- University Heart Center Hamburg, Clinic for general and interventional cardiology
- Cinzia Sala
- Division of Genetics and Cell Biology, San Raffaele Scientific Institute
- Cornelia M. van Duijn
- Department of Epidemiology, Genetic Epidemiology Unit, Erasmus University Medical Center
- Aude Saint-Pierre
- Center for Biomedicine, European Academy of Bozen/Bolzano (EURAC), affiliated to the University of Lübeck
- Daniel Ackermann
- Nephrology Division, Department of Specialties of Internal Medicine, Geneva University Hospital
- Daniel Shriner
- Center for Research on Genomics and Global Health, National Human Genome Research Institute
- Daniela Ruggiero
- Institute of Genetics and Biophysics "Adriano Buzzati-Traverso"—CNR
- Daniela Toniolo
- Division of Genetics and Cell Biology, San Raffaele Scientific Institute
- Yingchang Lu
- The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai
- Daniele Cusi
- Department of Health Sciences, University of Milano
- Darina Czamara
- Max Planck Institute of Psychiatry
- David Ellinghaus
- Institute of Clinical Molecular Biology, Christian-Albrechts University of Kiel
- David S. Siscovick
- Departments of Epidemiology and Medicine, Cardiovascular Health Research Unit, University of Washington
- Douglas Ruderfer
- Division of Psychiatric Genomics, Department of Psychiatry, Icahn School of Medicine at Mount Sinai
- Christian Gieger
- Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Harald Grallert
- Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Elena Rochtchina
- Westmead Millennium Institute, Centre for Vision Research, University of Sydney
- Elizabeth J. Atkinson
- Division of Biomedical Statistics and Informatics, Mayo Clinic
- Elizabeth G. Holliday
- Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, University of Newcastle, HMRI Building1, Kookaburra Circuit
- Eric Boerwinkle
- Human Genetics Center, University of Texas Health Science Center at Houston
- Erika Salvi
- Department of Health Sciences, University of Milano
- Erwin P. Bottinger
- The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai
- Federico Murgia
- Institute of Population Genetics—CNR
- Fernando Rivadeneira
- Department of Internal Medicine, Erasmus University Medical Center
- Florian Ernst
- Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald
- Florian Kronenberg
- Division of Genetic Epidemiology, Innsbruck Medical University
- Frank B. Hu
- Department of Nutrition, Harvard School of Public Health
- Gerjan J. Navis
- Department of Internal Medicine, University Medical Center Groningen, University of Groningen
- Gary C. Curhan
- Brigham and Women’s Hospital and Channing Laboratory, Harvard Medical School
- George B. Ehret
- Department of Specialties of Internal Medicine, Cardiology, Geneva University Hospitals
- Georg Homuth
- Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald
- Stefan Coassin
- Division of Genetic Epidemiology, Innsbruck Medical University
- Gian-Andri Thun
- Swiss Tropical and Public Health Institute
- Giorgio Pistis
- Division of Genetics and Cell Biology, San Raffaele Scientific Institute
- Giovanni Gambaro
- Division of Nephrology, Department of Internal Medicine and Medical Specialties, Columbus-Gemelli University Hospital, Catholic University
- Giovanni Malerba
- Department of Life and Reproduction Sciences, University of Verona
- Grant W. Montgomery
- Genetic Epidemiology, Queensland Institute of Medical Research, QIMR, PO Royal Brisbane Hospital
- Gudny Eiriksdottir
- Icelandic Heart Association, Research Institute
- Gunnar Jacobs
- Institute of Epidemiology and Biobank popgen, Christian-Albrechts University
- Guo Li
- Departments of Epidemiology and Medicine, Cardiovascular Health Research Unit, University of Washington
- H-Erich Wichmann
- Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health
- Harry Campbell
- Centre for Population Health Sciences, University of Edinburgh
- Helena Schmidt
- Department of Neurology, Austrian Stroke Prevention Study, Institute of Molecular Biology and Biochemistry, Medical University Graz
- Henri Wallaschofski
- Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald
- Henry Völzke
- Institute for Community Medicine, University of Greifswald
- Hermann Brenner
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ)
- Heyo K. Kroemer
- Institute of Pharmacology, University of Greifswald
- Holly Kramer
- Department of Public Health Sciences, Loyola Medical Center
- Honghuang Lin
- Boston University School of Medicine
- I. Mateo Leach
- Department of Cardiology, University Medical Center Groningen, University of Groningen
- Ian Ford
- Robertson Centre for Biostatistics, University of Glasgow
- Idris Guessous
- Division of Primary Care Medicine, Department of Community Medicine, Primary Care and Emergency Medicine, Geneva University Hospitals, Faculty of Medicine, University of Geneva
- Igor Rudan
- Centre for Population Health Sciences, University of Edinburgh
- Inga Prokopenko
- Department of Genomics of Common Disease, School of Public Health, Imperial College London
- Ingrid Borecki
- Division of Statistical Genomics, Washington University School of Medicine
- Iris M. Heid
- Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg
- Ivana Kolcic
- Croatian Centre for Global Health, University of Split Medical School
- Ivana Persico
- Institute of Population Genetics—CNR
- J. Wouter Jukema
- Department of Cardiology, Leiden University Medical Center
- James F. Wilson
- Centre for Population Health Sciences, University of Edinburgh
- Janine F. Felix
- Department of Epidemiology, Erasmus University Medical Center
- Jasmin Divers
- Division of Public Health Sciences, Department of Biostatistical Sciences, Wake Forest University Health Sciences
- Jean-Charles Lambert
- INSERM U744, Institut Pasteur de Lille
- Jeanette M. Stafford
- Division of Public Health Sciences, Department of Biostatistical Sciences, Wake Forest University Health Sciences
- Jean-Michel Gaspoz
- Division of Primary Care Medicine, Department of Community Medicine, Primary Care and Emergency Medicine, Geneva University Hospitals, Faculty of Medicine, University of Geneva
- Jennifer A. Smith
- Department of Epidemiology, School of Public Health, University of Michigan
- Jessica D. Faul
- Survey Research Center, Institute for Social Research, University of Michigan
- Jie Jin Wang
- Centre for Vision Research, Westmead Millennium Institute, University of Sydney
- Jingzhong Ding
- Department of Internal Medicine/Geriatrics, Wake Forest School of Medicine
- Joel N. Hirschhorn
- Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children’s Hospital
- John Attia
- Division of Biomedical Statistics and Informatics, Mayo Clinic
- John B. Whitfield
- Genetic Epidemiology, Queensland Institute of Medical Research, QIMR, PO Royal Brisbane Hospital
- John Chalmers
- University of Sydney, The George Institute for Global Health
- Jorma Viikari
- Department of Medicine, University of Turku, Turku University Hospital
- Josef Coresh
- Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health
- Joshua C. Denny
- Vanderbilt University School of Medicine, 448 Eskind Biomedical Library, 2209 Garland Avenue, Nashville, Tennessee 37212, USA
- Juha Karjalainen
- Department of Genetics, University of Groningen, University Medical Centre Groningen
- Jyotika K. Fernandes
- Division of Endocrinology, Medical University of South Carolina
- Karlhans Endlich
- Institute of Anatomy and Cell Biology, University of Greifswald
- Katja Butterbach
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ)
- Keith L. Keene
- Department of Biology, Center for Health Disparities, East Carolina University
- Kurt Lohman
- Internal Medicine Department, Wake Forest School of Medicine
- Laura Portas
- Institute of Population Genetics—CNR
- Lenore J. Launer
- Intramural Research Program, Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Gateway Building
- Leo-Pekka Lyytikäinen
- Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere, School of Medicine
- Loic Yengo
- CNRS UMR 8199
- Lude Franke
- Department of Genetics, University of Groningen, University Medical Centre Groningen
- Luigi Ferrucci
- Clinical Research Branch, National Institute on Aging
- Lynda M. Rose
- Preventive Medicine, Brigham and Women’s Hospital
- Lyudmyla Kedenko
- First Department of Internal Medicine, Paracelsus Medical University/Salzburger Landeskliniken
- Madhumathi Rao
- Division of Nephrology/Tufts Evidence Practice Center, Tufts University School of Medicine, Tufts Medical Center
- Maksim Struchalin
- Department of Epidemiology and Biostatistics, Erasmus University Medical Center
- Marcus E. Kleber
- Medical Clinic V, Medical Faculty Mannheim, Heidelberg University
- Margherita Cavalieri
- Department of Neurology, Division of Special Neurology, Austrian Stroke Prevention Study, Medical University Graz
- Margot Haun
- Division of Genetic Epidemiology, Innsbruck Medical University
- Marilyn C. Cornelis
- Department of Nutrition, Harvard School of Public Health
- Marina Ciullo
- Institute of Genetics and Biophysics "Adriano Buzzati-Traverso"—CNR
- Mario Pirastu
- Institute of Population Genetics—CNR
- Mariza de Andrade
- Division of Biomedical Statistics and Informatics, Mayo Clinic
- Mark A. McEvoy
- Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Hunter Medical Research Institute, John Hunter Hospital
- Mark Woodward
- Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health
- Martin Adam
- Swiss Tropical and Public Health Institute
- Massimiliano Cocca
- Division of Genetics and Cell Biology, San Raffaele Scientific Institute
- Matthias Nauck
- Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald
- Medea Imboden
- Swiss Tropical and Public Health Institute
- Melanie Waldenberger
- Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Menno Pruijm
- Service of Nephrology, Lausanne University Hospital
- Marie Metzger
- Inserm UMRS 1018, CESP Team 10, Université Paris-Sud
- Michael Stumvoll
- Department of Medicine, University of Leipzig
- Michele K. Evans
- Health Disparities Research Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, NIH Biomedical Center
- Michele M. Sale
- Department of Medicine (Cardiovascular Medicine), Center for Public Health Genomics, University of Virginia
- Mika Kähönen
- Department of Clinical Physiology, Tampere University Hospital, University of Tampere, School of Medicine
- Mladen Boban
- Croatian Centre for Global Health, University of Split Medical School
- Murielle Bochud
- University Institute of Social and Preventive Medicine, Centre Hospitalier Universitaire Vaudois, University of Lausanne
- Myriam Rheinberger
- Department of Nephrology, University Hospital Regensburg, Franz-Josef-Strauß-Allee 11, Regensburg 93053, Germany
- Niek Verweij
- Department of Cardiology, University Medical Center Groningen, University of Groningen
- Nabila Bouatia-Naji
- INSERM UMR970, Paris Cardiovascular Research Center (PARCC)
- Nicholas G. Martin
- Genetic Epidemiology, Queensland Institute of Medical Research, QIMR, PO Royal Brisbane Hospital
- Nick Hastie
- MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
- Nicole Probst-Hensch
- Swiss Tropical and Public Health Institute
- Nicole Soranzo
- Wellcome Trust Sanger Institute
- Olivier Devuyst
- University of Zurich, Institute of Physiology, Mechanisms of Inherited Kidney Disorders Group
- Olli Raitakari
- Department of Clinical Physiology, Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku University Hospital
- Omri Gottesman
- The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai
- Oscar H. Franco
- Department of Epidemiology, Erasmus University Medical Center
- Ozren Polasek
- Croatian Centre for Global Health, University of Split Medical School
- Paolo Gasparini
- Institute for Maternal and Child Health—IRCCS "Burlo Garofolo" and University of Trieste
- Patricia B. Munroe
- Department Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London
- Paul M. Ridker
- Harvard Medical School
- Paul Mitchell
- Centre for Vision Research, Westmead Millennium Institute, University of Sydney
- Paul Muntner
- Department of Medicine, University of Alabama at Birmingham
- Christa Meisinger
- Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health
- Johannes H. Smit
- Department of Psychiatry and EMGO+ Institute, VU University Medical Center
- ICBP Consortium
- AGEN Consortium
- CARDIOGRAM
- CHARGe-Heart Failure Group
- ECHOGen Consortium
- Peter Kovacs
- IFB AdiposityDiseases, University of Leipzig
- Philipp S. Wild
- Medical University Center Mainz
- Philippe Froguel
- CNRS UMR 8199
- Rainer Rettig
- Institute of Physiology, University of Greifswald
- Reedik Mägi
- Estonian Genome Center of University of Tartu (EGCUT)
- Reiner Biffar
- Clinic for Prosthodontic Dentistry, Gerostomatology and Material Science, University of Greifswald
- Reinhold Schmidt
- Department of Neurology, Division of Special Neurology, Austrian Stroke Prevention Study, Medical University Graz
- Rita P. S. Middelberg
- Genetic Epidemiology, Queensland Institute of Medical Research, QIMR, PO Royal Brisbane Hospital
- Robert J. Carroll
- Vanderbilt University School of Medicine, 448 Eskind Biomedical Library, 2209 Garland Avenue, Nashville, Tennessee 37212, USA
- Brenda W. Penninx
- Department of Psychiatry and EMGO+ Institute, VU University Medical Center
- Rodney J. Scott
- School of Biomedical Sciences and Pharmacy, University of Newcastle, Hunter Medical Research Institute, John Hunter Hospital
- Ronit Katz
- Kidney Research Institute, University of Washington
- Sanaz Sedaghat
- Department of Epidemiology, Erasmus University Medical Center
- Sarah H. Wild
- Centre for Population Health Sciences, University of Edinburgh
- Sharon L. R. Kardia
- Department of Epidemiology, School of Public Health, University of Michigan
- Sheila Ulivi
- Institute for Maternal and Child Health—IRCCS "Burlo Garofolo"
- Shih-Jen Hwang
- NHLBI's Framingham Heart Study and the Center for Population Studies
- Stefan Enroth
- Department of Immunology, Uppsala University, Genetics and Pathology, Biomedical Center, SciLifeLab, Uppsala University
- Stefan Kloiber
- Max Planck Institute of Psychiatry
- Stella Trompet
- Department of Cardiology, Leiden University Medical Center
- Benedicte Stengel
- Inserm UMRS 1018, CESP Team 10, Université Paris-Sud
- Stephen J. Hancock
- Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, University of Newcastle, HMRI Building1, Kookaburra Circuit
- Stephen T. Turner
- Department of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic
- Sylvia E. Rosas
- Renal Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania
- Sylvia Stracke
- INSERM U744, Institut Pasteur de Lille
- Tamara B. Harris
- Intramural Research Program, Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Gateway Building
- Tanja Zeller
- University Heart Center Hamburg, Clinic for general and interventional cardiology
- Tatijana Zemunik
- Croatian Centre for Global Health, University of Split Medical School
- Terho Lehtimäki
- Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere, School of Medicine
- Thomas Illig
- Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health
- Thor Aspelund
- Icelandic Heart Association, Research Institute
- Tiit Nikopensius
- Estonian Genome Center of University of Tartu (EGCUT)
- Tonu Esko
- Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children’s Hospital
- Toshiko Tanaka
- Clinical Research Branch, National Institute on Aging
- Ulf Gyllensten
- Department of Immunology, Uppsala University, Genetics and Pathology, Biomedical Center, SciLifeLab, Uppsala University
- Uwe Völker
- Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald
- Valur Emilsson
- Icelandic Heart Association, Research Institute
- Veronique Vitart
- MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
- Ville Aalto
- Department of Clinical Physiology, Turku University Hospital, Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku
- Vilmundur Gudnason
- Icelandic Heart Association, Research Institute
- Vincent Chouraki
- INSERM U744, Institut Pasteur de Lille
- Wei-Min Chen
- Department of Medicine (Cardiovascular Medicine), Center for Public Health Genomics, University of Virginia
- Wilmar Igl
- Department of Immunology, Uppsala University, Genetics and Pathology, Biomedical Center, SciLifeLab, Uppsala University
- Winfried März
- Synlab Academy, Synlab Services GmbH
- Wolfgang Koenig
- Department of Internal Medicine II—Cardiology, University of Ulm Medical Centre
- Wolfgang Lieb
- Institute of Epidemiology and Biobank popgen, Christian-Albrechts University
- Ruth J. F. Loos
- The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai
- Yongmei Liu
- Internal Medicine Department, Wake Forest School of Medicine
- Harold Snieder
- Department of Epidemiology, Unit of Genetic Epidemiology and Bioinformatics, University Medical Center Groningen
- Peter P. Pramstaller
- Center for Biomedicine, European Academy of Bozen/Bolzano (EURAC), affiliated to the University of Lübeck
- Afshin Parsa
- Division of Nephrology, University of Maryland Medical School
- Jeffrey R. O’Connell
- Department of Medicine, University of Maryland School of Medicine
- Katalin Susztak
- Renal Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania
- Pavel Hamet
- CRCHUM, University of Montreal, CHUM Research Center, Technopôle Angus
- Johanne Tremblay
- CRCHUM, University of Montreal, CHUM Research Center, Technopôle Angus
- Ian H. de Boer
- Kidney Research Institute, University of Washington
- Carsten A. Böger
- Department of Nephrology, University Hospital Regensburg, Franz-Josef-Strauß-Allee 11, Regensburg 93053, Germany
- Wolfram Goessling
- Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School
- Daniel I. Chasman
- Preventive Medicine, Brigham and Women’s Hospital
- Anna Köttgen
- Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health
- W. H. Linda Kao
- Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health
- Caroline S. Fox
- NHLBI's Framingham Heart Study and the Center for Population Studies
- DOI
- https://doi.org/10.1038/ncomms10023
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 19
Abstract
Reduced glomerular filtration rate (eGFR) is a hallmark of chronic kidney disease. Here, Pattaro et al. conduct a meta-analysis to discover several new loci associated with variation in eGFR and find that genes associated with eGFR loci often encode proteins potentially related to kidney development.
