Nature Communications (Aug 2019)

Bidirectional prefrontal-hippocampal dynamics organize information transfer during sleep in humans

  • Randolph F. Helfrich,
  • Janna D. Lendner,
  • Bryce A. Mander,
  • Heriberto Guillen,
  • Michelle Paff,
  • Lilit Mnatsakanyan,
  • Sumeet Vadera,
  • Matthew P. Walker,
  • Jack J. Lin,
  • Robert T. Knight

DOI
https://doi.org/10.1038/s41467-019-11444-x
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 16

Abstract

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How are memories transferred from short-term to long-term storage? Here, the authors show that during deep (NREM) sleep, the prefrontal cortex initiates rapid, bidirectional interactions to trigger information transfer from the hippocampus to the neocortex.