Structure-mediated modulation of mRNA abundance by A-to-I editing

Anneke Brümmer; Yun Yang; Tracey W. Chan; Xinshu Xiao

doi:10.1038/s41467-017-01459-7

Nature Communications (Nov 2017)

Structure-mediated modulation of mRNA abundance by A-to-I editing

Anneke Brümmer,
Yun Yang,
Tracey W. Chan,
Xinshu Xiao

Affiliations

Anneke Brümmer: Department of Integrative Biology and Physiology, Bioinformatics Interdepartmental Program, Molecular Biology Institute, University of California Los Angeles
Yun Yang: Department of Integrative Biology and Physiology, Bioinformatics Interdepartmental Program, Molecular Biology Institute, University of California Los Angeles
Tracey W. Chan: Department of Integrative Biology and Physiology, Bioinformatics Interdepartmental Program, Molecular Biology Institute, University of California Los Angeles
Xinshu Xiao: Department of Integrative Biology and Physiology, Bioinformatics Interdepartmental Program, Molecular Biology Institute, University of California Los Angeles

DOI: https://doi.org/10.1038/s41467-017-01459-7
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 13

Abstract

Read online

RNA A-to-I editing introduces single nucleotide changes to RNA, but its role in cells remains unclear. Here, the authors analyse A-to-I editomes in human samples and find that A-to-I editing stabilizes RNA secondary structures and reduces the accessibility of AGO2-miRNA to target sites in mRNAs.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal