Development and Characterization of Wound Dressing Material Coated with Natural Extracts of Curcumin, Aloe vera and Chitosan Solution Enhanced with rhEGF (REGEN-DTM)

Abstract

In this work, the leave extracts of Aloe vera, piper betel and neem leaf were prepared and coated on bamboo fiber based material for wound dressing applications. The fabrics coated with different compositions of the natural extract were enhanced with rhEGF (REGEN-D™ 150). The FTIR confirms the presence of alcoholic and phenolic group which were responsible for antibacterial activity. The SEM morphology of the developed dressing material was porous nature and more suitable for the process of curing wound. In antimicrobial tests, the zone of incubation of E. coli and S. aureus ranges from 18 mm and 22. In vivo study using albino rats induced with diabetes reveals that the wound healing rate is increased in the range of 25% to 54% compared to a negative-control group. Overall, the natural extracts coated dressing material has considerable potential and well suited for clinical application that was evidenced through antimicrobial and in vivo study results. Therefore, natural extracts coated on bamboo-based dressing materials are claimed to have helpful nature for wound healing and the current study will be one of the platforms for natural extracts coated material-based medical textile applications.

Keywords

• antimicrobial
• bamboo
• medical textiles
• natural extracts
• wound dressing
• wound healing