NLRC5 shields T lymphocytes from NK-cell-mediated elimination under inflammatory conditions

Kristina Ludigs; Camilla Jandus; Daniel T. Utzschneider; Francesco Staehli; Stéphanie Bessoles; Anh Thu Dang; Giorgia Rota; Wilson Castro; Dietmar Zehn; Eric Vivier; Werner Held; Pedro Romero; Greta Guarda

doi:10.1038/ncomms10554

Nature Communications (Feb 2016)

NLRC5 shields T lymphocytes from NK-cell-mediated elimination under inflammatory conditions

Kristina Ludigs,
Camilla Jandus,
Daniel T. Utzschneider,
Francesco Staehli,
Stéphanie Bessoles,
Anh Thu Dang,
Giorgia Rota,
Wilson Castro,
Dietmar Zehn,
Eric Vivier,
Werner Held,
Pedro Romero,
Greta Guarda

Affiliations

Kristina Ludigs: Department of Biochemistry, University of Lausanne
Camilla Jandus: Ludwig Center for Cancer Research of the University of Lausanne
Daniel T. Utzschneider: Division of Allergology and Immunology, CHUV, University of Lausanne
Francesco Staehli: Department of Biochemistry, University of Lausanne
Stéphanie Bessoles: Ludwig Center for Cancer Research of the University of Lausanne
Anh Thu Dang: Department of Biochemistry, University of Lausanne
Giorgia Rota: Department of Biochemistry, University of Lausanne
Wilson Castro: Department of Biochemistry, University of Lausanne
Dietmar Zehn: Division of Allergology and Immunology, CHUV, University of Lausanne
Eric Vivier: Centre d’Immunologie de Marseille-Luminy, Aix-Marseille University UM2
Werner Held: Ludwig Center for Cancer Research of the University of Lausanne
Pedro Romero: Ludwig Center for Cancer Research of the University of Lausanne
Greta Guarda: Department of Biochemistry, University of Lausanne

DOI: https://doi.org/10.1038/ncomms10554
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 10

Abstract

Read online

NK cell tolerance to self-MHCI levels is calibrated during their development. Here the authors show that this tolerance is overcome by an inflammatory environment and that NLRC5 protects T cells from NK cell-mediated elimination by maintaining high MHCI expression.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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