Nature Communications (Jun 2019)

The hydrolase LpqI primes mycobacterial peptidoglycan recycling

  • Patrick J. Moynihan,
  • Ian T. Cadby,
  • Natacha Veerapen,
  • Monika Jankute,
  • Marialuisa Crosatti,
  • Galina V. Mukamolova,
  • Andrew L. Lovering,
  • Gurdyal S. Besra

DOI
https://doi.org/10.1038/s41467-019-10586-2
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 11

Abstract

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Bacterial growth and division require remodelling of the cell wall, which generates free peptidoglycan fragments. Here, Moynihan et al. show that Mycobacterium tuberculosis can recycle components of their peptidoglycan, and characterise a crucial enzyme required for this process.