Xin yixue (Feb 2024)

Relationship between Hp infection and serum gastrointestinal hormones and monoamine neurotransmitter levels in patients with ulcerative colitis

  • Wang Ruixue, Zhang Feng, Zhang Qiang

DOI
https://doi.org/10.3969/j.issn.0253-9802.2024.02.009
Journal volume & issue
Vol. 55, no. 2
pp. 122 – 126

Abstract

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Objective To investigate the relationship between Helicobacter pylori （Hp） infection and serum gastrointestinal hormones and monoamine neurotransmitter levels in patients with ulcerative colitis. Methods 145 patients newly diagnosed with ulcerative colitis were selected into the study group，and 140 patients without abnormal results by gastrointestinal endoscopy were assigned into the control group. In two groups，Hp infection was diagnosed by using 13C urea breath test （13C-UBT）. The levels of gastrointestinal hormones（substance P （SP），endothelin （ET），vasoactive intestinal peptide （VIP））and monoamine neurotransmitters（norepinephrine （NE），5-hydroxytryptamine （5-HT）） were detected. Serum levels of gastrointestinal hormones and monoamine neurotransmitters were compared between active and remission phase patients in the study group. Serum levels of gastrointestinal hormones and monoamine neurotransmitters were compared between Hp-positive and -negative patients. The relationship between Hp infection and gastrointestinal hormone- and monoamine neurotransmitter-related indexes in patients with ulcerative colitis was assessed by Logistic regression analysis. Results Hp infection rate and VIP level in the study group were lower，whereas the levels of SP，ET，NE，and 5-HT were higher than those in the control group （all P<0.05）. Hp infection rate and VIP level in the active phase group were lower，while the levels of SP，ET，NE，and 5-HT were higher than those in the remission phase group （all P<0.05）. In the study group，the levels of SP，ET，NE and 5-HT in Hp-positive patients were lower，whereas the level of VIP was higher compared with those in Hp-negative counterparts （all P<0.05）. Logistic regression analysis showed that SP，ET，NE and 5-HT were the protective factors for Hp infection in patients with ulcerative colitis （all P<0.05），while elevated level of VIP was the risk factor （P<0.05）. Conclusions In ulcerative colitis patients，there are differences in the levels of gastrointestinal hormones and monoamine neurotransmitters between patients with and without Hp infection. Hp infection may be correlated with the changes in the levels of gastrointestinal hormones and monoamine neurotransmitters.

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