Nature Communications (May 2020)
A PKB-SPEG signaling nexus links insulin resistance with diabetic cardiomyopathy by regulating calcium homeostasis
- Chao Quan,
- Qian Du,
- Min Li,
- Ruizhen Wang,
- Qian Ouyang,
- Shu Su,
- Sangsang Zhu,
- Qiaoli Chen,
- Yang Sheng,
- Liang Chen,
- Hong Wang,
- David G. Campbell,
- Carol MacKintosh,
- Zhongzhou Yang,
- Kunfu Ouyang,
- Hong Yu Wang,
- Shuai Chen
Affiliations
- Chao Quan
- State Key Laboratory of Pharmaceutical Biotechnology, Department of Cardiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Model Animal Research Center, Nanjing University
- Qian Du
- State Key Laboratory of Pharmaceutical Biotechnology, Department of Cardiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Model Animal Research Center, Nanjing University
- Min Li
- State Key Laboratory of Pharmaceutical Biotechnology, Department of Cardiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Model Animal Research Center, Nanjing University
- Ruizhen Wang
- State Key Laboratory of Pharmaceutical Biotechnology, Department of Cardiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Model Animal Research Center, Nanjing University
- Qian Ouyang
- MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University
- Shu Su
- MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University
- Sangsang Zhu
- State Key Laboratory of Pharmaceutical Biotechnology, Department of Cardiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Model Animal Research Center, Nanjing University
- Qiaoli Chen
- State Key Laboratory of Pharmaceutical Biotechnology, Department of Cardiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Model Animal Research Center, Nanjing University
- Yang Sheng
- State Key Laboratory of Pharmaceutical Biotechnology, Department of Cardiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Model Animal Research Center, Nanjing University
- Liang Chen
- State Key Laboratory of Pharmaceutical Biotechnology, Department of Cardiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Model Animal Research Center, Nanjing University
- Hong Wang
- Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University
- David G. Campbell
- MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee
- Carol MacKintosh
- Division of Cell and Developmental Biology, School of Life Sciences, University of Dundee
- Zhongzhou Yang
- State Key Laboratory of Pharmaceutical Biotechnology, Department of Cardiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Model Animal Research Center, Nanjing University
- Kunfu Ouyang
- Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University
- Hong Yu Wang
- MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University
- Shuai Chen
- State Key Laboratory of Pharmaceutical Biotechnology, Department of Cardiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Model Animal Research Center, Nanjing University
- DOI
- https://doi.org/10.1038/s41467-020-16116-9
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 14
Abstract
Molecular mechanisms linking myocardial insulin resistance to diabetic cardiomyopathy are incompletely understood. Here the authors show that myocardial insulin resistance impairs a PKB-SPEG-SERCA2a signaling axis, which contributes to the development of diabetic cardiomyopathy.
