Frontiers in Microbiology (Sep 2022)
Genome-wide analysis reveals the emergence of multidrug resistant Stenotrophomonas acidaminiphila strain SINDOREI isolated from a patient with sepsis
- Ying Zhang,
- Ying Zhang,
- Ying Zhang,
- Ying Zhang,
- Danhua Li,
- Qun Yan,
- Ping Xu,
- Ping Xu,
- Wei Chen,
- Hongya Xin,
- Hongya Xin,
- Hongya Xin,
- Hongya Xin,
- Dengshu Wu,
- Dengshu Wu,
- Dengshu Wu,
- Dengshu Wu,
- Mingxiang Zhou,
- Yajing Xu,
- Yajing Xu,
- Yajing Xu,
- Yajing Xu,
- Ao Zhang,
- Ao Zhang,
- Ao Zhang,
- Ao Zhang,
- Wenjia Wei,
- Wenjia Wei,
- Wenjia Wei,
- Wenjia Wei,
- Zhiping Jiang,
- Zhiping Jiang,
- Zhiping Jiang,
- Zhiping Jiang
Affiliations
- Ying Zhang
- Department of Hematology, Xiangya Hospital, Central South University, Changsha, China
- Ying Zhang
- National Clinical Research Center for Geriatric Diseases, Xiangya Hospital, Changsha, China
- Ying Zhang
- Hunan Hematology Oncology Clinical Medical Research Center, Changsha, China
- Ying Zhang
- National Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital of Soochow University, Suzhou, China
- Danhua Li
- Departmant of Scientific Affairs, Hugobiotech Co. Ltd., Beijing, China
- Qun Yan
- Department of Laboratory Medicine, Xiangya Hospital, Central South University, Changsha, China
- Ping Xu
- Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, China
- Ping Xu
- Institute of Clinical Pharmacy, Central South University, Changsha, China
- Wei Chen
- Department of Gastroenterology, Changsha Central Hospital, Changsha, China
- Hongya Xin
- Department of Hematology, Xiangya Hospital, Central South University, Changsha, China
- Hongya Xin
- National Clinical Research Center for Geriatric Diseases, Xiangya Hospital, Changsha, China
- Hongya Xin
- Hunan Hematology Oncology Clinical Medical Research Center, Changsha, China
- Hongya Xin
- National Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital of Soochow University, Suzhou, China
- Dengshu Wu
- Department of Hematology, Xiangya Hospital, Central South University, Changsha, China
- Dengshu Wu
- National Clinical Research Center for Geriatric Diseases, Xiangya Hospital, Changsha, China
- Dengshu Wu
- Hunan Hematology Oncology Clinical Medical Research Center, Changsha, China
- Dengshu Wu
- National Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital of Soochow University, Suzhou, China
- Mingxiang Zhou
- Department of Laboratory Medicine, Xiangya Hospital, Central South University, Changsha, China
- Yajing Xu
- Department of Hematology, Xiangya Hospital, Central South University, Changsha, China
- Yajing Xu
- National Clinical Research Center for Geriatric Diseases, Xiangya Hospital, Changsha, China
- Yajing Xu
- Hunan Hematology Oncology Clinical Medical Research Center, Changsha, China
- Yajing Xu
- National Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital of Soochow University, Suzhou, China
- Ao Zhang
- Department of Hematology, Xiangya Hospital, Central South University, Changsha, China
- Ao Zhang
- National Clinical Research Center for Geriatric Diseases, Xiangya Hospital, Changsha, China
- Ao Zhang
- Hunan Hematology Oncology Clinical Medical Research Center, Changsha, China
- Ao Zhang
- National Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital of Soochow University, Suzhou, China
- Wenjia Wei
- Department of Hematology, Xiangya Hospital, Central South University, Changsha, China
- Wenjia Wei
- National Clinical Research Center for Geriatric Diseases, Xiangya Hospital, Changsha, China
- Wenjia Wei
- Hunan Hematology Oncology Clinical Medical Research Center, Changsha, China
- Wenjia Wei
- National Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital of Soochow University, Suzhou, China
- Zhiping Jiang
- Department of Hematology, Xiangya Hospital, Central South University, Changsha, China
- Zhiping Jiang
- National Clinical Research Center for Geriatric Diseases, Xiangya Hospital, Changsha, China
- Zhiping Jiang
- Hunan Hematology Oncology Clinical Medical Research Center, Changsha, China
- Zhiping Jiang
- National Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital of Soochow University, Suzhou, China
- DOI
- https://doi.org/10.3389/fmicb.2022.989259
- Journal volume & issue
-
Vol. 13
Abstract
Stenotrophomonas acidaminiphila, the most recent reported species in genus Stenotrophomonas, is a relatively rare bacteria and is an aerobic, glucose non-fermentative, Gram-negative bacterium. However, little information of S. acidaminiphila is known to cause human infections. In this research, we firstly reported a multidrug-resistant strain S. acidaminiphila SINDOREI isolated from the blood of a patient with sepsis, who was dead of infection eventually. The whole genome of strain SINDOREI was sequenced, and genome comparisons were performed among six closely related S. acidaminiphila strains. The core genes (2,506 genes) and strain-specific genes were identified, respectively, to know about the strain-level diversity in six S. acidaminiphila stains. The presence of a unique gene (narG) and essential genes involved in biofilm formation in strain SINDOREI are important for the pathogenesis of infections. Strain SINDOREI was resistant to trimethoprim/sulfamethoxazole, ciprofloxacin, ofloxacin, cefepime, ceftazidime, and aztreonam. Several common and specific antibiotic resistance genes were identified in strain SINDOREI. The presence of two sul genes and exclusive determinants GES-1, aadA3, qacL, and cmlA5 is responsible for the resistance to multidrug. The virulence factors and resistance determinants can show the relationship between the phenotype and genotype and afford potential therapeutic strategies for infections.
Keywords
- Stenotrophomonas acidaminiphila
- sepsis
- genome sequencing
- genome comparisons
- virulence factors
- multidrug resistant
