Cell-based receptor discovery identifies host factors specifically targeted by the SARS CoV-2 spike

Bushra Husain; Kobe Yuen; Dawei Sun; Shengya Cao; Jian Payandeh; Nadia Martinez-Martin

doi:10.1038/s42003-022-03695-0

Communications Biology (Aug 2022)

Cell-based receptor discovery identifies host factors specifically targeted by the SARS CoV-2 spike

Bushra Husain,
Kobe Yuen,
Dawei Sun,
Shengya Cao,
Jian Payandeh,
Nadia Martinez-Martin

Affiliations

Bushra Husain: Bayer AG, Portfolio and Assays group
Kobe Yuen: Genentech, Oncology Biomarker development department
Dawei Sun: Genentech, Structural Biology Department
Shengya Cao: Genentech, Microchemistry, Proteomics and Lipidomics department. Receptor Discovery group
Jian Payandeh: Exelixis
Nadia Martinez-Martin: Regeneron Pharmaceuticals, Infectious Disease department

DOI: https://doi.org/10.1038/s42003-022-03695-0
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 12

Abstract

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A high-throughput cell-based platform is developed for systematic investigation of receptor-ligand interactions and applied to identify cell-surface proteins that bind to SARS CoV-2.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal