Nature Communications (May 2021)
Peripheral and lung resident memory T cell responses against SARS-CoV-2
- Judith Grau-Expósito,
- Nerea Sánchez-Gaona,
- Núria Massana,
- Marina Suppi,
- Antonio Astorga-Gamaza,
- David Perea,
- Joel Rosado,
- Anna Falcó,
- Cristina Kirkegaard,
- Ariadna Torrella,
- Bibiana Planas,
- Jordi Navarro,
- Paula Suanzes,
- Daniel Álvarez-Sierra,
- Alfonso Ayora,
- Irene Sansano,
- Juliana Esperalba,
- Cristina Andrés,
- Andrés Antón,
- Santiago Ramón y Cajal,
- Benito Almirante,
- Ricardo Pujol-Borrell,
- Vicenç Falcó,
- Joaquín Burgos,
- María J. Buzón,
- Meritxell Genescà
Affiliations
- Judith Grau-Expósito
- Infectious Diseases Department, Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus
- Nerea Sánchez-Gaona
- Infectious Diseases Department, Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus
- Núria Massana
- Infectious Diseases Department, Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus
- Marina Suppi
- Infectious Diseases Department, Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus
- Antonio Astorga-Gamaza
- Infectious Diseases Department, Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus
- David Perea
- Infectious Diseases Department, Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus
- Joel Rosado
- Thoracic Surgery and Lung Transplantation Department, Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus
- Anna Falcó
- Infectious Diseases Department, Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus
- Cristina Kirkegaard
- Infectious Diseases Department, Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus
- Ariadna Torrella
- Infectious Diseases Department, Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus
- Bibiana Planas
- Infectious Diseases Department, Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus
- Jordi Navarro
- Infectious Diseases Department, Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus
- Paula Suanzes
- Infectious Diseases Department, Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus
- Daniel Álvarez-Sierra
- Diagnostic Immunology Group, Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus
- Alfonso Ayora
- Occupational Risk Prevention Unit, Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus
- Irene Sansano
- Pathology Department, Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus
- Juliana Esperalba
- Respiratory Viruses Unit, Microbiology Department, Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus
- Cristina Andrés
- Respiratory Viruses Unit, Microbiology Department, Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus
- Andrés Antón
- Respiratory Viruses Unit, Microbiology Department, Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus
- Santiago Ramón y Cajal
- Pathology Department, Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus
- Benito Almirante
- Infectious Diseases Department, Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus
- Ricardo Pujol-Borrell
- Diagnostic Immunology Group, Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus
- Vicenç Falcó
- Infectious Diseases Department, Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus
- Joaquín Burgos
- Infectious Diseases Department, Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus
- María J. Buzón
- Infectious Diseases Department, Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus
- Meritxell Genescà
- Infectious Diseases Department, Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus
- DOI
- https://doi.org/10.1038/s41467-021-23333-3
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 17
Abstract
Lung resident memory T (TRM) cells are important for protection from viral infection in the lungs. Here the authors use paired lung biopsy material and blood to characterize T cell responses in patients with COVID-19 over time and find persistence of antiviral lung TRM cells that might be important to limit reinfection.
