P104: BASE EDITING REPAIRS THE HBE MUTATION RESTORING THE PRODUCTION OF NORMAL GLOBIN CHAINS IN SEVERE HBE/β-THALASSEMIA PATIENT HEMATOPOIETIC STEM AND ERYTHROID CELLS

• M Badat,
• P Hua,
• S Mettananda,
• C Fisher,
• N Roy,
• S Rice,
• A Roy,
• D Higgs,
• J Davies

Affiliations

M Badat

1 Barts Health NHS Trust, London, UNITED KINGDOM

P Hua

2 Weatherall Institute of Molecular Medicine, Oxford, UNITED KINGDOM

S Mettananda

3 University of Kelaniya, Ragama, SRI LANKA

C Fisher

2 Weatherall Institute of Molecular Medicine, Oxford, UNITED KINGDOM

N Roy

4 Dept Haematology, Oxford University Hospitals NHS Trust, Oxford, UNITED KINGDOM

S Rice

2 Weatherall Institute of Molecular Medicine, Oxford, UNITED KINGDOM

A Roy

2 Weatherall Institute of Molecular Medicine, Oxford, UNITED KINGDOM

D Higgs

2 Weatherall Institute of Molecular Medicine, Oxford, UNITED KINGDOM

J Davies

2 Weatherall Institute of Molecular Medicine, Oxford, UNITED KINGDOM