Abstract Glucose‐6‐phosphate dehydrogenase (G6PD) deficiency affects over 400 million people worldwide. The most common variant of G6PD deficiency in the United States is the A‐variant, which is present amongst African‐Americans. Most people with this variant, however, do not experience severe hemolysis unless under extreme circumstances. Here, we present the case of a 44‐year‐old African‐American male who under circumstances of multiple admissions for critical illness eventually presented with a masked diagnosis of G6PD deficiency.
