Nature Communications (Jul 2019)
The histone methyltransferase Setd2 is indispensable for V(D)J recombination
- Zhongzhong Ji,
- Yaru Sheng,
- Juju Miao,
- Xiaoxia Li,
- Huifang Zhao,
- Jinming Wang,
- Chaping Cheng,
- Xue Wang,
- Kaiyuan Liu,
- Kai Zhang,
- Longmei Xu,
- Jufang Yao,
- Lijing Shen,
- Jian Hou,
- Wenhao Zhou,
- Jinqiao Sun,
- Li Li,
- Wei-Qiang Gao,
- Helen He Zhu
Affiliations
- Zhongzhong Ji
- State Key Laboratory of Oncogenes and Related Genes, Renji-Med-X Clinical Stem Cell Research Center, and Department of Urology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University
- Yaru Sheng
- State Key Laboratory of Oncogenes and Related Genes, Renji-Med-X Clinical Stem Cell Research Center, and Department of Urology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University
- Juju Miao
- State Key Laboratory of Oncogenes and Related Genes, Renji-Med-X Clinical Stem Cell Research Center, and Department of Urology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University
- Xiaoxia Li
- State Key Laboratory of Oncogenes and Related Genes, Renji-Med-X Clinical Stem Cell Research Center, and Department of Urology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University
- Huifang Zhao
- State Key Laboratory of Oncogenes and Related Genes, Renji-Med-X Clinical Stem Cell Research Center, and Department of Urology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University
- Jinming Wang
- State Key Laboratory of Oncogenes and Related Genes, Renji-Med-X Clinical Stem Cell Research Center, and Department of Urology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University
- Chaping Cheng
- State Key Laboratory of Oncogenes and Related Genes, Renji-Med-X Clinical Stem Cell Research Center, and Department of Urology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University
- Xue Wang
- State Key Laboratory of Oncogenes and Related Genes, Renji-Med-X Clinical Stem Cell Research Center, and Department of Urology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University
- Kaiyuan Liu
- State Key Laboratory of Oncogenes and Related Genes, Renji-Med-X Clinical Stem Cell Research Center, and Department of Urology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University
- Kai Zhang
- State Key Laboratory of Oncogenes and Related Genes, Renji-Med-X Clinical Stem Cell Research Center, and Department of Urology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University
- Longmei Xu
- State Key Laboratory of Oncogenes and Related Genes, Renji-Med-X Clinical Stem Cell Research Center, and Department of Urology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University
- Jufang Yao
- State Key Laboratory of Oncogenes and Related Genes, Renji-Med-X Clinical Stem Cell Research Center, and Department of Urology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University
- Lijing Shen
- Department of Hematology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University
- Jian Hou
- Department of Hematology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University
- Wenhao Zhou
- Genetic Center, Children’s Hospital of Fudan University
- Jinqiao Sun
- Genetic Center, Children’s Hospital of Fudan University
- Li Li
- State Key Laboratory of Oncogenes and Related Genes, Renji-Med-X Clinical Stem Cell Research Center, and Department of Urology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University
- Wei-Qiang Gao
- State Key Laboratory of Oncogenes and Related Genes, Renji-Med-X Clinical Stem Cell Research Center, and Department of Urology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University
- Helen He Zhu
- State Key Laboratory of Oncogenes and Related Genes, Renji-Med-X Clinical Stem Cell Research Center, and Department of Urology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University
- DOI
- https://doi.org/10.1038/s41467-019-11282-x
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 13
Abstract
The repertoire of adaptive immune receptor is generated by V(D)J recombination, somatic rearrangements of V, D and J gene segments, in the respective loci. Here the authors show that the deficiency of Setd2, a histone methyl transfer, impairs V(D)J recombination and induces severe developmental blocks in both T and B lineages.
